Berberine alleviates experimental colitis by enhancing gut-microbiota-dependent intestinal barrier function and suppressing gasdermin D activation

Figure 6 Berberine protects mice from dextran sulfate sodium-induced colitis in a microbiota-dependent manner. A: Design of the cohousing experiment on dextran sulfate sodium-treated mice; B: Percentage change in body weight; C: Disease activity index scores of mice during colitis; D: Statistical analysis of colon length data from each group; E: Representative images of hematoxylin and eosin-stained colon samples; F: Histological scores of the colonic tissues. The data shown are the mean ± SEM (n = 10). DSS: Dextran sulfate sodium; BerB-H: Berberine high-dose group; Co-H: Cohousing; DAI: Disease activity index.