Berberine alleviates experimental colitis by enhancing gut-microbiota-dependent intestinal barrier function and suppressing gasdermin D activation

Figure 4 Transplantation of microbiota altered by berberine recapitulates the effects of berberine treatment on dextran sulfate sodium-induced colitis. A: Design of the fecal microbiota transplantation experiment on dextran sulfate sodium-treated mice; B: Disease activity index scores of fecal microbiota transplantation mice during colitis; C: Percentage change in body weight; D: Colon length; E: Representative images of hematoxylin and eosin-stained colon samples; F: Histological scores of colonic tissues. The data shown are the mean ± SEM (n = 10). ^bP < 0.01, ^cP < 0.001. PBS: Phosphate-buffered saline; Berb: Berberine; ABX: Antibiotics; DSS: Dextran sulfate sodium; DAI: Disease activity index; FMT: Fecal microbiota transplantation.