Berberine alleviates experimental colitis by enhancing gut-microbiota-dependent intestinal barrier function and suppressing gasdermin D activation

Figure 3 Berberine regulates gut microbiota diversity and structure. A: Venn diagram of gut microbiota; B: Alpha diversity index; C: Βeta diversity, including non-metric multidimensional scaling and principal analysis; D-F: Relative abundance histograms at the phylum, class, and order levels; G: Linear discriminant analysis scores for bacterial taxa significantly enriched in the gut microbiota from each group (linear discriminant analysis score > 4). The data shown are the mean ± SEM (n = 8). ^aP < 0.05. LDA: Linear discriminant analysis; CON: Control; DSS: Dextran sulfate sodium; Berb-L: Berberine low-dose group; Berb-H: Berberine high-dose group; LDA: Linear discriminant analysis.