Exercise-responsive skeletal muscle genes mechanistically linked to metabolic dysfunction-associated steatotic liver disease

Figure 4 Weighted gene co-expression network analysis of differentially expressed genes. A: Scale-free topology fitting index (left) and mean connectivity (right) across soft-thresholding powers (β), with the red line indicating the threshold correlation coefficient of 0.9; B: Gene clustering dendrogram constructed using the topological overlap matrix, with color bars representing an co-expression modules; C: Heatmap illustrating the correlation between module eigengenes and clinical traits in metabolic dysfunction-associated steatotic liver disease subjects before and after exercise, with positive correlations in red and negative in blue; D: Scatter plot of gene significance vs module membership in the mediumpurple3 module; E: Scatter plot of gene significance vs module membership in the powder blue module. Con: Pre-exercise; Train: Post-exercise.