Baseline hepatitis B surface antigen and cirrhosis predict extended interferon therapy in chronic hepatitis B: A retrospective study

doi:10.3748/wjg.v32.i12.116287

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Mar 28, 2026; 32(12): 116287
Published online Mar 28, 2026. doi: 10.3748/wjg.v32.i12.116287

Table 2 Baseline characteristics of subgroups based on the duration of pegylated interferon α-2b therapy in the training cohort, mean ± SD/n (%)

Characteristic	Overall (n = 196)	The regular course (< 48 weeks) (n = 160)	The extended course (≥ 48 weeks) (n = 36)	P value
Age (year)	41.15 ± 7.88	41.69 ± 8.01	38.72 ± 6.82	0.041
Gender				0.800
Male	118 (60.20)	97 (60.62)	21 (58.33)
Female	78 (39.80)	63 (39.38)	15 (41.67)
Treatment regimen				0.420
IFN monotherapy	99 (50.51)	83 (51.88)	16 (44.44)
Combined with ETV	97 (49.49)	77 (48.12)	20 (55.56)
Cirrhosis				0.004
(-)	170 (86.73)	144 (90.00)	26 (72.22)
(+)	26 (13.27)	16 (10.00)	10 (27.78)
HBeAg				0.059
(-)	179 (91.33)	149 (93.12)	30 (83.33)
(+)	17 (8.67)	11 (6.88)	6 (16.67)
HBV DNA (log₁₀ copies/mL)	1.65 ± 1.85	1.63 ± 1.72	1.74 ± 2.39	0.765
HBsAg (IU/mL), median (Q1, Q3)	47.80 (5.56, 469.24)	27.05 (2.50, 230.15)	60.19 (60.39, 1878.06)	0.002
HBsAg (log₁₀ IU/mL)	1.61 ± 1.28	1.35 ± 1.20	2.75 ± 0.97	< 0.001
12-week HBsAg (log₁₀ IU/mL), median (Q1, Q3)	-0.24 (-1.51, 1.37)	-0.47 (-1.68, 0.83)	1.94 (0.36, 2.75)	< 0.001
HBsAg decline at 12 weeks (log₁₀ IU/mL), median (Q1, Q3)	1.58 (0.59, 2.72)	1.68 (0.72, 2.72)	0.75 (0.16, 2.60)	0.240
ALT (U/L), median (Q1, Q3)	24.00 (15.93 37.38)	24.00 (15.38, 35.60)	25.50 (20.35, 44.58)	0.681
TBiL (μmol/L)	16.79 ± 10.60	17.02 ± 11.25	15.75 ± 7.09	0.518
ALP (U/L)	74.46 ± 33.45	75.22 ± 35.56	71.08 ± 21.78	0.504
GGT (U/L), median (Q1, Q3)	21.50 (14.00, 32.25)	21.50 (14.00, 33.25)	21.50 (14.75, 28.25)	0.682
ALB				0.776
< 40	189 (96.43)	154 (96.25)	35 (97.22)
≥ 40	7 (3.57)	6 (3.75)	1 (2.78)
WBC (10⁹/L), median (Q1, Q3)	5.51 (4.57, 6.66)	5.46 (4.36, 6.66)	5.63 (4.94, 6.48)	0.918
HB (g/L)	146.28 ± 26.96	146.54 ± 26.68	145.09 ± 28.53	0.771
PLT (10⁹/L)	215.57 ± 57.89	216.75 ± 60.08	210.33 ± 47.33	0.549

Q1: 1st quartile; Q3: 3st quartile; IFN: Interferon; ETV: Entecavir; HBeAg: Hepatitis B envelope antigen; HBV: Hepatitis B virus; HBsAg: Hepatitis B surface antigen; ALT: Alanine aminotransferase; TBiL: Total bilirubin; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transferase; ALB: Albumin; WBC: White blood cell; HB: Hemoglobin; PLT: Platelet.

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Citation: Yan F, Xue XL, Guo Y, Zhang QR, You RR, Shang J, Wu XP, Geng JW, Gao XH, Ye Q, Liang J, Wang XY, Zeng JY, Chen J, Lin YC, Chen XY, Du Q, Yin WL, Liu L, Wang F, Xu BG, Zhang WH, Xiang HL. Baseline hepatitis B surface antigen and cirrhosis predict extended interferon therapy in chronic hepatitis B: A retrospective study. World J Gastroenterol 2026; 32(12): 116287
URL: https://www.wjgnet.com/1007-9327/full/v32/i12/116287.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i12.116287

Yan F, Xue XL, Guo Y, Zhang QR, You RR, Shang J, Wu XP, Geng JW, Gao XH, Ye Q, Liang J, Wang XY, Zeng JY, Chen J, Lin YC, Chen XY, Du Q, Yin WL, Liu L, Wang F, Xu BG, Zhang WH, Xiang HL. Baseline hepatitis B surface antigen and cirrhosis predict extended interferon therapy in chronic hepatitis B: A retrospective study. World J Gastroenterol 2026; 32(12): 116287 [DOI: 10.3748/wjg.v32.i12.116287]

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