ST2 gene deficiency alleviates acute gastric injury in mice by modulating inflammation and epithelial cell death

Figure 3 Interleukin-33 upregulation in acute gastric injury enhances type 1 cytotoxic activation and dendritic cells recruitment. A: Interleukin-33 mRNA expression levels in gastric tissue following ethanol administration, measured by real-time quantitative reverse transcriptase polymerase chain reaction; B: Total count of dendritic cells (CD11c+), including the subsets expressing CD86 and producing interleukin-12, assessed by flow cytometry; C-E: Total count and representative flow cytometry dot plots of CD8+ cells in ethanol-treated mice; quantification of CD8+ cells subsets (C). Producing interferon-γ and CD107a (D), and expressing the inhibitory molecules killer cell lectin-like receptor subfamily G member 1 and cytotoxic T-lymphocyte-associated protein 4 (E). Results are displayed as mean ± SEM; n = 10 mice per group. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. WT: Wild type; ST2: Suppression of tumorigenicity 2; IFN: Interferon; KLRG1: Killer cell lectin-like receptor subfamily G member 1; CTLA-4: Cytotoxic T-lymphocyte-associated protein 4.