ST2 gene deficiency alleviates acute gastric injury in mice by modulating inflammation and epithelial cell death

Figure 2 Attenuated systemic and local proinflammatory milieu in suppression of tumorigenicity 2 gene knockout mice during acute gastric injury. A: Concentrations of interleukin (IL)-1β, tumor necrosis factor-α (TNF-α), IL-17, interferon (IFN)-γ, and IL-10 in gastric tissue homogenates; B: Ratios of proinflammatory to anti-inflammatory cytokines (IL-1β/IL-10, TNF-α/IL-10, IL-17/IL-10, and IFN-γ/IL-10) in gastric tissue to evaluate the inflammatory balance; C: Serum concentrations of IL-1β, TNF-α, IL-17, IFN-γ, IL-6, and IL-10. Cytokine levels were measured using enzyme-linked immunosorbent assay. Results are displayed as mean ± SEM; n = 10 mice per group. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. WT: Wild type; ST2: Suppression of tumorigenicity 2; IFN: Interferon; TNF-α: Tumor necrosis factor-α.