ST2 gene deficiency alleviates acute gastric injury in mice by modulating inflammation and epithelial cell death

Figure 1 Suppression of tumorigenicity 2 gene deficiency mitigates acute gastric injury. A: Representative macroscopic images of gastric tissue showing differences in the severity of mucosal damage following ethanol exposure; B and C: Quantitative evaluation of macroscopic gastric injury. Gastric lesion score (%) (B) and ulcer area (mm²) (C) were determined by capturing digital images of the inner gastric surface and analyzing them using ImageJ software; D: Microscopic assessment of tissue damage based on histological activity index; E: Representative hematoxylin and eosin staining images of gastric tissue sections (magnified × 10 and × 40) illustrating differences in epithelial integrity, inflammatory infiltration, and overall tissue architecture between experimental groups. Data are presented as mean ± SEM; n = 10 mice per group. ^aP < 0.05, ^bP < 0.01. WT: Wild type; ST2: Suppression of tumorigenicity 2.