ST2 gene deficiency alleviates acute gastric injury in mice by modulating inflammation and epithelial cell death

doi:10.3748/wjg.v32.i12.114576

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Mar 28, 2026; 32(12): 114576
Published online Mar 28, 2026. doi: 10.3748/wjg.v32.i12.114576

Table 2 Correlation between systemic concentration of cytokines of interest and histological score

Cytokines	Histological score
IL-1β	r = 0.971¹^,^b; P = 0.001¹
TNF-α	r = 0.883¹^,^a; P = 0.020¹
IL-17	r = 0.765; P = 0.076
IFN-γ	r = 0.736; P = 0.096
IL-6	r = 0.912¹^,^a; P = 0.011¹

¹Significant values of Spearman’s rank correlation coefficients.

^aP < 0.05.

^bP < 0.001.

IL-1β: Interleukin-1β; TNF-α: Tumor necrosis factor-α; IL-17: Interleukin-17; IFN-γ: Interferon-γ; IL-6: Interleukin-6.

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Citation: Corovic IF, Pantic JM, Stanisavljevic IA, Pavlovic SM, Jovanovic IP, Radosavljevic GD, Simovic Markovic BJ. ST2 gene deficiency alleviates acute gastric injury in mice by modulating inflammation and epithelial cell death. World J Gastroenterol 2026; 32(12): 114576
URL: https://www.wjgnet.com/1007-9327/full/v32/i12/114576.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i12.114576

Corovic IF, Pantic JM, Stanisavljevic IA, Pavlovic SM, Jovanovic IP, Radosavljevic GD, Simovic Markovic BJ. ST2 gene deficiency alleviates acute gastric injury in mice by modulating inflammation and epithelial cell death. World J Gastroenterol 2026; 32(12): 114576 [DOI: 10.3748/wjg.v32.i12.114576]

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