Role of hepatic sonic hedgehog protein expression in the diagnosis of metabolic dysfunction-associated steatohepatitis

doi:10.3748/wjg.v32.i12.113939

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World Journal of Gastroenterology

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1007-9327

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Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Mar 28, 2026; 32(12): 113939
Published online Mar 28, 2026. doi: 10.3748/wjg.v32.i12.113939

Table 2 Comparison of pathological parameters in metabolic dysfunction-associated steatotic liver and metabolic dysfunction-associated steatohepatitis patients, n (%)

	MASL (n = 78)	MASH (n = 112)	P value
Steatosis			0.000
Score 1	71 (91.03)	21 (18.75)
Score 2	6 (7.69)	50 (44.64)
Score 3	1 (1.28)	41 (36.61)
Ballooned hepatocytes with H&E staining and SHH + CK8/18 immunostaining			0.000
Score 0	37 (47.44)	0
Score 1	41 (52.56)	49 (43.75)
Score 2	0	63 (56.25)
Lobular inflammation			0.000
Score 0	2 (2.56)	0
Score 1	56 (71.79)	4 (3.57)
Score 2	19 (24.36)	48 (42.86)
Score 3	1 (1.28)	60 (53.57)
Fibrosis			0.000
Score 0	39 (50.0)	11 (9.82)
Score 1	30 (38.46)	31 (27.68)
Score 2	8 (10.26)	32 (28.57)
Score 3	1 (1.28)	30 (26.79)
Score 4	0	8 (7.14)

P < 0.05 indicates statistically significant difference. MASL: Metabolic dysfunction-associated steatotic liver; MASH: Metabolic dysfunction-associated steatohepatitis; H&E: Hematoxylin and eosin; SHH: Sonic hedgehog; CK8/18: Cytokeratin 8/18.

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Citation: Han X, Chen MY, Xiong QF, Zhong YD, Liu DX, Li J, Yang YF. Role of hepatic sonic hedgehog protein expression in the diagnosis of metabolic dysfunction-associated steatohepatitis. World J Gastroenterol 2026; 32(12): 113939
URL: https://www.wjgnet.com/1007-9327/full/v32/i12/113939.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i12.113939

Han X, Chen MY, Xiong QF, Zhong YD, Liu DX, Li J, Yang YF. Role of hepatic sonic hedgehog protein expression in the diagnosis of metabolic dysfunction-associated steatohepatitis. World J Gastroenterol 2026; 32(12): 113939 [DOI: 10.3748/wjg.v32.i12.113939]

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