Role of hepatic sonic hedgehog protein expression in the diagnosis of metabolic dysfunction-associated steatohepatitis

doi:10.3748/wjg.v32.i12.113939

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World Journal of Gastroenterology

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1007-9327

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Retrospective Cohort Study

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World J Gastroenterol. Mar 28, 2026; 32(12): 113939
Published online Mar 28, 2026. doi: 10.3748/wjg.v32.i12.113939

Table 1 Comparison of clinical parameters in metabolic dysfunction-associated steatotic liver and metabolic dysfunction-associated steatohepatitis patients, n (%)

	MASL (n = 78)	MASH (n = 112)	P value
Sex (male)	48 (61.54)	57 (50.89)	0.147
Age (year)	45.54 ± 12.93	43.77 ± 15.34	0.391
BMI (kg/m², median)	23.31 (22.2, 25.9)	25.75 (23.9, 27.9)	0.000
Hypertension	16 (20.51)	34 (30.36)	0.130
Diabetes	5 (6.14)	24 (21.43)	0.005
Metabolic syndrome	17 (21.52)	43 (38.74)	0.011
ALT (U/L, median)	49.60 (29.6, 87.1)	98.60 (69.2, 163.1)	0.000
AST (U/L, median)	28.750 (20.5, 40.1)	56.550 (39.8, 81.0)	0.000
GGT (U/L, median)	86.950 (28.9, 207.1)	80.75 (45.2, 127.0)	0.520
ALP (U/L, median)	91.70 (73.0, 117.0)	86.30 (71.6, 105.0)	0.261
ALB	43.90 (41.5, 47.1)	45.050 (42.5, 47.0)	0.341
TBIL	13.450 (9.6, 18.3)	13.300 (9.6, 17.1)	0.610
BUN	4.700 (4.1, 5.8)	4.460 (3.8, 5.5)	0.143
Cr	68.0 (58.0, 81.5)	65.50 (52.8, 77.0)	0.132
UA	348.0 (272.8, 402.0)	364.50 (299.5, 449.0)	0.028
TG	1.710 (1.1, 2.3)	1.570 (1.3, 2.2)	0.823
TC	4.50 (3.9, 5.2)	4.760 (4.3, 5.5)	0.078
LDL	2.89 ± 0.78	3.10 ± 0.82	0.092
HDL	1.11 ± 0.26	1.09 ± 0.21	0.602
GLU	5.240 (4.7, 5.6)	5.425 (4.9, 6.1)	0.011
M30	153.0 (153.0, 228.6)	476.0 (391.1, 549.0)	0.000
M65	168.0 (153.3, 282.0)	579.0 (537.1, 621.3)	0.000
CAP	250.0 (228.5, 261.0)	291.0 (276.5, 313.0)	0.000
LSM	5.050 (4.1, 6.7)	7.40 (4.7, 10.2)	0.003
NFS	2.283 (1.8, 2.6)	2.626 (2.0, 3.2)	0.006

P < 0.05 indicates statistically significant difference. Nonalcoholic fatty liver disease fibrosis score = -1.675 + 0.037 × age + 0.094 × body mass index (kg/m²) + 1.13 × [impaired fasting glucose or diabetes (yes = 1, no = 0)] + 0.99 × aspartate aminotransferase/alanine aminotransferase - 0.013 × platelet (× 10⁹/L) - 0.66 × albumin (g/dL). MASL: Metabolic dysfunction-associated steatotic liver; MASH: Metabolic dysfunction-associated steatohepatitis; BMI: Body mass index; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transferase; ALP: Alkaline phosphatase; ALB: Albumin; TBIL: Total bilirubin; BUN: Blood urea nitrogen; Cr: Creatinine; UA: Uric acid; TG: Triglyceride; TC: Total cholesterol; LDL: Low-density lipoprotein; HDL: High-density lipoprotein; GLU: Glucose; CAP: Controlled attenuation parameter; LSM: Liver stiffness measurement; NFS: Nonalcoholic fatty liver disease fibrosis score.

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Citation: Han X, Chen MY, Xiong QF, Zhong YD, Liu DX, Li J, Yang YF. Role of hepatic sonic hedgehog protein expression in the diagnosis of metabolic dysfunction-associated steatohepatitis. World J Gastroenterol 2026; 32(12): 113939
URL: https://www.wjgnet.com/1007-9327/full/v32/i12/113939.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i12.113939

Han X, Chen MY, Xiong QF, Zhong YD, Liu DX, Li J, Yang YF. Role of hepatic sonic hedgehog protein expression in the diagnosis of metabolic dysfunction-associated steatohepatitis. World J Gastroenterol 2026; 32(12): 113939 [DOI: 10.3748/wjg.v32.i12.113939]

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