Autophagy related RHEB-CSF1R complex promotes tumor metastasis via advancing phosphorylation levels of PI3K, AKT, mTOR in pancreatic cancer

Figure 3 High Ras homolog enriched in brain expression indicated poor prognosis and poor sensitivity to chemotherapy in pancreatic cancer. A: Kaplan-Meier analysis of external validation patients’ high-Ras homolog enriched in brain (RHEB) and low-RHEB groups (n = 44); B: Kaplan-Meier analysis of The Cancer Genome Atlas’ high-RHEB and low-RHEB groups (n = 177); C: Univariate and multivariate analyses of prognostic factors; D: Multivariate Cox regression analyses of prognostic factors in The Cancer Genome Atlas; E: A constructed nomogram for prognostic prediction of pancreatic cancer patients; F: Calibration curves of the prognostic model in predicting the overall survival probability at 1/2/3 years; G: Receiver operating characteristic curves of the model of pancreatic adenocarcinoma patients at 1/2/3 years; H: Receiver operating characteristic curves of RHEB of pancreatic adenocarcinoma patients at 1/2/3 years. AUC: Area under the curve; HR: Hazard ratio; RHEB: Ras homolog enriched in brain; CI: Confidence interval; TPR: True positive rate; FPR: False positive rate.