Autophagy related RHEB-CSF1R complex promotes tumor metastasis via advancing phosphorylation levels of PI3K, AKT, mTOR in pancreatic cancer

doi:10.3748/wjg.v32.i12.112725

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World Journal of Gastroenterology

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1007-9327

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Mar 28, 2026; 32(12): 112725
Published online Mar 28, 2026. doi: 10.3748/wjg.v32.i12.112725

Table 1 Sequences of the transferred vectors

	Sequences
Negative control	UUCUCCGAACGUGUCACGU(dT)(dT)
Negative control	ACGUGACACGUUCGGAGAA(dT)(dT)
RHEB/siRNA	RHEB-siRNA1: GTGTATTCTGTTACATCAA
	RHEB-siRNA2: CACAGTAAATGGACAAGAA
	RHEB-siRNA3: GAAAGACCTGCATATGGAA
RHEB/shRNA	RHEB-shRNA1: CCGGCCTCAGACATACTCCATAGATCTCGAGATCTATGGAGTATGTCTGAGGTTTTTT
	RHEB-shRNA2: CCGGTTATGTTGGTTGGGAATAAGACTCGAGTCTTATTCCCAACCAACATAATTTTTT
	RHEB-shRNA3: CCGGCCTACGATCCAACCATAGAAACTCGAGTTTCTATGGTTGGATCGTAGGTTTTTT
	RHEB-shRNA4: CCGGTATCATCTTCAACTTGTAGACCTCGAGGTCTACAAGTTGAAGATGATATTTTTT
CSF1R/shRNA	CSF1R-shRNA1: CTGCTGACTGTTGAGACCTTA
	CSF1R-shRNA2: CGACTATAAGAACATCCACCT
	CSF1R-shRNA3: CCAACAACGCTACCTTCCAAA
	CSF1R-shRNA4: ACAGGAGAGAGCGGGACTATA

RHEB: Ras homolog enriched in brain; siRNA: Small interfering RNA; shRNA: Short hairpin RNA; CSF1R: Colony stimulating factor 1 receptor.

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Citation: Deng QX, Yang K, He J, Li JF, Li XQ, Zou L, Li YM, Xu SM, Jiang Z, Wu LJ. Autophagy related RHEB-CSF1R complex promotes tumor metastasis via advancing phosphorylation levels of PI3K, AKT, mTOR in pancreatic cancer. World J Gastroenterol 2026; 32(12): 112725
URL: https://www.wjgnet.com/1007-9327/full/v32/i12/112725.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i12.112725

Deng QX, Yang K, He J, Li JF, Li XQ, Zou L, Li YM, Xu SM, Jiang Z, Wu LJ. Autophagy related RHEB-CSF1R complex promotes tumor metastasis via advancing phosphorylation levels of PI3K, AKT, mTOR in pancreatic cancer. World J Gastroenterol 2026; 32(12): 112725 [DOI: 10.3748/wjg.v32.i12.112725]

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