Impact of metabolic dysfunction-associated steatotic liver disease on liver metastasis and survival in pancreatic cancer

Table 5 Risk factors for mortality in patients with liver metastasis

Variables	Univariate			Multivariate
	HR	95%CI	P value	HR	95%CI	P value
Age (years)	1.019	1.009-1.028	< 0.001	1.021	1.001-1.041	0.043
Male	0.975	0.816-1.165	0.782
Diabetes mellitus	0.682	0.569-0.819	< 0.001	0.648	0.423-0.992	0.046
Hypertension	0.989	0.828-1.182	0.904
Cirrhosis	4.304	1.071-17.290	0.040
Body mass index (kg/m2)	0.993	0.964-1.023	0.639
Tumor size	1.013	1.006-1.020	< 0.001	1.017	1.005-1.029	0.007
HSI	1.000	0.986-1.016	0.953
HSI > 30	0.820	0.661-1.018	0.072
HSI > 36	0.993	0.822-1.199	0.942
TG (mg/dL)	0.997	0.995-1.000	0.022	0.997	0.994-1.000	0.031
HDL (mg/dL)	0.998	0.987-1.008	0.667
LDL (mg/dL)	0.997	0.992-1.002	0.199
CA19-9 > 260 (U/mL)	1.690	1.407-2.029	< 0.001	1.312	0.892-1.928	0.168

HR: Hazard ratio; CI: Confidence interval; HSI: Hepatic steatosis index; TG: Triglyceride; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; CA: Carbohydrate antigen.