Lactobacillus acidophilus attenuates polyethylene glycol-induced susceptibility to Citrobacter rodentium infection via microbiota modulation

Figure 3 Polyethylene glycol results in an infection window of 14 days. A: Mice were gavaged with polyethylene glycol 7-day before infection with Citrobacter rodentium (CR); B: CR load of the feces; C and D: Colon length; E and F: Representative hematoxylin and eosin staining (20 ×) and pathological score of the inflamed colon epithelium; G and H: The mRNA expression of the tumor necrosis factor-α and interferon-γ of the inflamed colon; I: Mice were gavaged with polyethylene glycol 14-day before infection with CR; J: CR load of the feces; K and L: Representative hematoxylin and eosin staining (20 ×) and pathological score of the inflamed colon epithelium; M and N: The mRNA expression of the tumor necrosis factor-α and interferon-γ of the inflamed colon. Data are representative of at least two independent experiments. Data are shown as mean ± SD. CR: Citrobacter rodentium; CFUs: Colony-forming units; PEG: Polyethylene glycol; TNFα: Tumor necrosis factor-α; IFNγ: Interferon-γ.