Icariin inhibits tumor-associated neutrophil recruitment via the CXCL8-CXCR2 axis and restrains pro-metastatic programs in colorectal cancer

doi:10.3748/wjg.v32.i11.113325

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Mar 21, 2026; 32(11): 113325
Published online Mar 21, 2026. doi: 10.3748/wjg.v32.i11.113325

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Figure 11 Icariin suppresses epithelial-mesenchymal transition in colorectal cancer mice. A: The positive rate of protein E-cadherin and vimentin detected by immunohistochemistry; B: The relative expression of protein matrix metalloproteinase 2 and matrix metalloproteinase 9; C: Inflammatory factor levels. Results are illustrated as mean ± SD. ^aP < 0.05 vs the model group. ICA: Icariin; MMP: Matrix metalloproteinase; GAPDH: Glyceraldehyde 3-phosphate dehydrogenase; TNF-α: Tumor necrosis factor-α; IL-1β: Interleukin-1β.

Citation: Zhao YH, Chen J, Gong T, Ge HY, Li M. Icariin inhibits tumor-associated neutrophil recruitment via the CXCL8-CXCR2 axis and restrains pro-metastatic programs in colorectal cancer. World J Gastroenterol 2026; 32(11): 113325
URL: https://www.wjgnet.com/1007-9327/full/v32/i11/113325.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i11.113325

Zhao YH, Chen J, Gong T, Ge HY, Li M. Icariin inhibits tumor-associated neutrophil recruitment via the CXCL8-CXCR2 axis and restrains pro-metastatic programs in colorectal cancer. World J Gastroenterol 2026; 32(11): 113325 [DOI: 10.3748/wjg.v32.i11.113325]

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