Icariin inhibits tumor-associated neutrophil recruitment via the CXCL8-CXCR2 axis and restrains pro-metastatic programs in colorectal cancer

doi:10.3748/wjg.v32.i11.113325

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Mar 21, 2026; 32(11): 113325
Published online Mar 21, 2026. doi: 10.3748/wjg.v32.i11.113325

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Figure 7 Icariin inhibits recruitment of C-X-C motif chemokine receptor 2+ tumor-associated neutrophils predominantly via the C-X-C motif chemokine ligand 1-C-X-C motif chemokine receptor 2 axis. A and B: The proportion of C-X-C motif chemokine receptor 2+ tumor-associated neutrophils in the lower chamber. Results are illustrated as mean ± SD. ^aP < 0.05 vs the control group, ^bP < 0.05 vs the icariin group. ICA: Icariin; CXCL: C-X-C motif chemokine ligand; CXCR2: C-X-C motif chemokine receptor 2.

Citation: Zhao YH, Chen J, Gong T, Ge HY, Li M. Icariin inhibits tumor-associated neutrophil recruitment via the CXCL8-CXCR2 axis and restrains pro-metastatic programs in colorectal cancer. World J Gastroenterol 2026; 32(11): 113325
URL: https://www.wjgnet.com/1007-9327/full/v32/i11/113325.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i11.113325

Zhao YH, Chen J, Gong T, Ge HY, Li M. Icariin inhibits tumor-associated neutrophil recruitment via the CXCL8-CXCR2 axis and restrains pro-metastatic programs in colorectal cancer. World J Gastroenterol 2026; 32(11): 113325 [DOI: 10.3748/wjg.v32.i11.113325]

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