Gut bacterial and fungal signatures in relation to human leukocyte antigen-DQ2/DQ8 in children with celiac disease and siblings

doi:10.3748/wjg.v32.i10.116128

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World Journal of Gastroenterology

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1007-9327

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©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Mar 14, 2026; 32(10): 116128
Published online Mar 14, 2026. doi: 10.3748/wjg.v32.i10.116128

Table 4 Measures of bacterial and fungal beta diversity using the most common metrics in stool samples from pediatric patients with celiac disease, their siblings and a control group of children

Index	Bray-Curtis	Jensen-Shannon divergence	Jaccard
Taxa level¹	Bacteria
L2	0.238	0.05^a	3.79
L7	0.045^a	0.052	1.28
Taxa level¹	Fungi
L3	0.007^a	0.008^a	0.008^a
L7	0.031^a	0.029^a	0.029^a
Taxa level²	Bacteria
L2	0.284	0.028^a	0.137
L7	0.054	0.057	0.049^a
Taxa level²	Fungi
L3	0.851	0.889	0.805
L7	0.732	0.662	0.681
Taxa level³	Bacteria
L2	0.664	< 0.001^a	0.582
L7	0.038^a	0.042^a	0.037^a
Taxa level³	Fungi
L3	0.007^a	0.004^a	0.012^a
L7	0.02^a	0.005^a	0.44

¹Beta diversity metrics P values (celiac disease vs siblings of celiac disease).

²Beta diversity metrics P values (celiac disease vs control).

³Beta diversity metrics P values (siblings of celiac disease vs control).

^aP < 0.05.

L2: Phylum; L3: Class; L7: Species.

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Citation: Salamon D, Krawczyk A, Zapała B, Duplaga M, Kowalska-Duplaga K, Gosiewski T. Gut bacterial and fungal signatures in relation to human leukocyte antigen-DQ2/DQ8 in children with celiac disease and siblings. World J Gastroenterol 2026; 32(10): 116128
URL: https://www.wjgnet.com/1007-9327/full/v32/i10/116128.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i10.116128

Salamon D, Krawczyk A, Zapała B, Duplaga M, Kowalska-Duplaga K, Gosiewski T. Gut bacterial and fungal signatures in relation to human leukocyte antigen-DQ2/DQ8 in children with celiac disease and siblings. World J Gastroenterol 2026; 32(10): 116128 [PMID: 41809456 DOI: 10.3748/wjg.v32.i10.116128]

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