Gut bacterial and fungal signatures in relation to human leukocyte antigen-DQ2/DQ8 in children with celiac disease and siblings

Table 2 Clinical data from patients with celiac disease, siblings of celiac disease patients and healthy subjects (control group), n (%)

Variable	Category of variable	CeD, n = 14	Siblings of CeD, n = 16	Control group, n = 19	P value1	P value1,2	P value1,3	P value1,4
Sex	Female	7	7	16	0.033a	0.752	0.045a	0.045a
	Male	7	9	3
DQ2.2	Positive	4 (28.6)	4 (25)	3 (15.8)	0.655
	Negative	10 (71.4)	12 (75)	16 (84.2)
DQ2.5	Positive	14 (100)	8 (50)	3 (15.8)	< 0.001a	0.031a	< 0.05	0.071
	Negative	0 (0.0)	8 (50)	16 (84.2)
DQ8	Positive	1 (7.1)	1 (6.3)	6 (31.6)	0.071
	Negative	13 (92.9)	15 (93.8)	13 (68.4)

¹P value for χ² test with post hoc analysis.

²Celiac disease vs siblings of celiac disease.

³Celiac disease vs control group.

⁴Siblings of celiac disease vs control group.

^aP < 0.017 after Bonferroni correction.

CeD: Celiac disease.