Gut bacterial and fungal signatures in relation to human leukocyte antigen-DQ2/DQ8 in children with celiac disease and siblings

doi:10.3748/wjg.v32.i10.116128

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Mar 14, 2026; 32(10): 116128
Published online Mar 14, 2026. doi: 10.3748/wjg.v32.i10.116128

Table 1 Laboratory data from patients with celiac disease, siblings of celiac disease patients, and healthy subjects (control group), median (Q1-Q3)

Variable	CeD, n = 14	Siblings of CeD, n = 16	Control group, n = 19	P value¹	P value¹^,²	P value¹^,³	P value¹^,⁴
BMI (kg/m²)	15.28 (14.17-16.62)	16.81 (4.62-18.12)	19.51 (5.29-21.61)	0.026^a	0.35	0.021^a	0.8
Glycemia (mmol/L)	4.5 (4.43-4.78)	4.45 (4.32-4.68)	4.4 (4.25-4.7)	0.936
Total cholesterol (mmol/L)	3.95 (3.69-4.4)	4.42 (3.83-4.79)	3.83 (3.67-4.21)	0.005^a	0.24	0.65	0.004^a
HDL (mmol/L)	1.35 (1.24-1.56)	1.48 (1.32-1.7)	1.26 (1.1-1.42)	0.018^a	0.7	0.41	0.014^a
LDL (mmol/L)	2.47 (2.0-2.54)	2.72 (2.22-2.97)	2.36 (1.92-2.55)	0.019^a	0.12	1	0.017^a
TGs (mmol/L)	0.67 (0.58-0.88)	0.8 (0.72-0.96)	0.71 (0.66-0.8)	0.548
ALT (U/L)	24.0 (19.0-25.12)	23.5 (16.0-26.8)	15.0 (13.75-27.5)	0.83
Fe (μmol/L)	12.9 (10.4-19.7)	17.8 (13.1-21.05)	16.35 (14.4-21.25)	0.34
Creatinine (μmol/L)	34.45 (30.72-36.95)	35.4 (30.55-44.92)	51.55 (38.92-55.6)	0.003^a	1	0.013^a	0.011^a
Anti-tTG (U/mL)	173.9 (77.7-200.0)	2.0 (2.0-2.03)	1.9 (1.9-1.9)	< 0.001^a	< 0.001^a	< 0.001^a	< 0.001^a

¹P value for Kruskal-Wallis test with post hoc analysis.

²Celiac disease vs siblings of celiac disease.

³Celiac disease vs control group.

⁴Siblings of celiac disease vs control group.

^aP < 0.017 after Bonferroni correction.

BMI: Body mass index; HDL: High-density lipoprotein cholesterol; LDL: Low-density lipoprotein cholesterol; TGs: Triglycerides; ALT: Alanine aminotransferase; anti-tTG: Anti-tissue transglutaminase; CeD: Celiac disease.

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Citation: Salamon D, Krawczyk A, Zapała B, Duplaga M, Kowalska-Duplaga K, Gosiewski T. Gut bacterial and fungal signatures in relation to human leukocyte antigen-DQ2/DQ8 in children with celiac disease and siblings. World J Gastroenterol 2026; 32(10): 116128
URL: https://www.wjgnet.com/1007-9327/full/v32/i10/116128.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i10.116128

Salamon D, Krawczyk A, Zapała B, Duplaga M, Kowalska-Duplaga K, Gosiewski T. Gut bacterial and fungal signatures in relation to human leukocyte antigen-DQ2/DQ8 in children with celiac disease and siblings. World J Gastroenterol 2026; 32(10): 116128 [PMID: 41809456 DOI: 10.3748/wjg.v32.i10.116128]

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