Integrative study reveals NR1D1 mediates Hedyotis diffusa’s antifibrosis via hypoxia inducible factor-1/ammonia axis

doi:10.3748/wjg.v32.i10.115334

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World Journal of Gastroenterology

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1007-9327

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©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Mar 14, 2026; 32(10): 115334
Published online Mar 14, 2026. doi: 10.3748/wjg.v32.i10.115334

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Figure 7 Abnormally elevated ammonia levels promote LX2 cell activation. A: Ammonia level test by enzyme-linked immunosorbent assay kit; B: Immunofluorescence detection of α-smooth muscle actin expression; C: Laser confocal analysis of mitochondrial morphology. P value listed, compared with each group. CTRL: Control; NH₄Cl: Ammonium chloride; SMA: Smooth muscle actin; DAPI: 4’,6-diamidino-2-phenylindole.

Citation: Xia SW, Liu H, Yang KY, Gao YJ, Zhang MR, Zhou JW, Kong DS, Wu HY, Zhang F, Chen L. Integrative study reveals NR1D1 mediates Hedyotis diffusa’s antifibrosis via hypoxia inducible factor-1/ammonia axis. World J Gastroenterol 2026; 32(10): 115334
URL: https://www.wjgnet.com/1007-9327/full/v32/i10/115334.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i10.115334

Xia SW, Liu H, Yang KY, Gao YJ, Zhang MR, Zhou JW, Kong DS, Wu HY, Zhang F, Chen L. Integrative study reveals NR1D1 mediates Hedyotis diffusa’s antifibrosis via hypoxia inducible factor-1/ammonia axis. World J Gastroenterol 2026; 32(10): 115334 [PMID: 41809447 DOI: 10.3748/wjg.v32.i10.115334]

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