Integrative study reveals NR1D1 mediates Hedyotis diffusa’s antifibrosis via hypoxia inducible factor-1/ammonia axis

doi:10.3748/wjg.v32.i10.115334

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Mar 14, 2026; 32(10): 115334
Published online Mar 14, 2026. doi: 10.3748/wjg.v32.i10.115334

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Figure 6 NR1D1 is the primary target of Hedyotis diffusa injection for its anti-hepatic fibrosis effects. A: Hematoxylin-eosin, Masson, Sirius red and α-smooth muscle actin staining. Scale bar: 50 μm; B: Serum biochemical indices of liver injury; C: Serum biochemical indices of hepatic fibrosis. P value listed, compared with each group. SMA: Smooth muscle actin; HE: Hematoxylin-eosin; HDI: Hedyotis diffusa injection; CCl₄: Carbon tetrachloride; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; LDH: Lactate dehydrogenase; TBIL: Total bilirubin; LN: Laminin; HA: Hyaluronidase; PC-III: Procollagen-III; IV-C: Type IV collagen; KD: Knockdown.

Citation: Xia SW, Liu H, Yang KY, Gao YJ, Zhang MR, Zhou JW, Kong DS, Wu HY, Zhang F, Chen L. Integrative study reveals NR1D1 mediates Hedyotis diffusa’s antifibrosis via hypoxia inducible factor-1/ammonia axis. World J Gastroenterol 2026; 32(10): 115334
URL: https://www.wjgnet.com/1007-9327/full/v32/i10/115334.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i10.115334

Xia SW, Liu H, Yang KY, Gao YJ, Zhang MR, Zhou JW, Kong DS, Wu HY, Zhang F, Chen L. Integrative study reveals NR1D1 mediates Hedyotis diffusa’s antifibrosis via hypoxia inducible factor-1/ammonia axis. World J Gastroenterol 2026; 32(10): 115334 [PMID: 41809447 DOI: 10.3748/wjg.v32.i10.115334]

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