Integrative study reveals NR1D1 mediates Hedyotis diffusa’s antifibrosis via hypoxia inducible factor-1/ammonia axis

doi:10.3748/wjg.v32.i10.115334

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Mar 14, 2026; 32(10): 115334
Published online Mar 14, 2026. doi: 10.3748/wjg.v32.i10.115334

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Figure 1 Identification of the active ingredients of Hedyotis diffusa injection. A: Total ion chromatograms of Herba Hedyotidis medicated liver: Positive ion mode and negative ion mode; B: Chemical formula structure of the 6 main components.

Citation: Xia SW, Liu H, Yang KY, Gao YJ, Zhang MR, Zhou JW, Kong DS, Wu HY, Zhang F, Chen L. Integrative study reveals NR1D1 mediates Hedyotis diffusa’s antifibrosis via hypoxia inducible factor-1/ammonia axis. World J Gastroenterol 2026; 32(10): 115334
URL: https://www.wjgnet.com/1007-9327/full/v32/i10/115334.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i10.115334

Xia SW, Liu H, Yang KY, Gao YJ, Zhang MR, Zhou JW, Kong DS, Wu HY, Zhang F, Chen L. Integrative study reveals NR1D1 mediates Hedyotis diffusa’s antifibrosis via hypoxia inducible factor-1/ammonia axis. World J Gastroenterol 2026; 32(10): 115334 [PMID: 41809447 DOI: 10.3748/wjg.v32.i10.115334]

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