Vasopressin and fluid retention after liver resection: Comparison with the renin-angiotensin-aldosterone system by surgical extent and liver function

Figure 4 Incidence of hypervasopressinemia after liver resection according to surgical extent. The major liver resection (MajLR) group (orange bars) had a higher proportion of patients with plasma arginine vasopressin ≥ 4.0 pg/mL compared to the minor liver resection group (green bars). Hypervasopressinemia was significantly more frequent in the MajLR group on postoperative day (POD) 1 and 5. Although the early increase on POD 1 likely reflects intraoperative fluid-restrictive management and hemodynamic shifts inherent to major liver resection, the persistence to POD 5 despite postoperative rehydration suggests a prolonged neuroendocrine response proportional to surgical stress. ^aP < 0.05. MinLR: Minor liver resection; MajLR: Major liver resection; LR: Liver resection; POD: Postoperative day.