Vasopressin and fluid retention after liver resection: Comparison with the renin-angiotensin-aldosterone system by surgical extent and liver function

Table 3 Comparison of perioperative variables between patients undergoing minor and major liver resection, n (%)

	MinLR group (n = 45)	MajLR group (n = 11)	P value
Age (years), median (IQR)	69 (65-75)	69 (64-77)	0.942
Sex (men/women)	31 (68.9)/14 (31.1)	6 (54.6)/5 (45.5)	0.368
Indication of liver resection			0.053
Colorectal liver metastasis	23 (51.1)	2 (18.2)
Hepatocellular carcinoma	15 (33.3)	5 (45.5)
Biliary tract cancer	2 (4.4)	3 (27.3)
Others	5 (11.1)	1 (9.1)
Indocyanine green retention rate at 15 minutes (%), median (IQR)	10.0 (7.4-17.2)	10.4 (6.2-14.1)	0.458
Kinetic indocyanine green elimination rate constant, median (IQR)	0.155 (0.118-0.173)	0.165 (0.131-0.186)	0.265
Number of complete resected Couinaud segments, median (IQR)	0 (0-1)	3 (3-4)	< 0.001b
Laparoscopic surgery	19 (42.2)	3 (27.3)	0.363
Extrahepatic bile duct resection	0 (0.0)	4 (36.4)	< 0.001b
Concomitant colorectal resection	3 (6.7)	0 (0.0)	0.379
Operative duration (minute), median (IQR)	278 (207-337)	382 (301-665)	0.002b
Intraoperative blood loss (mL), median (IQR)	290 (67-484)	1124 (150-2188)	0.015a
Intraoperative red blood cell transfusion	7 (15.6)	4 (36.4)	0.119
Intraoperative fluid balance (mL/kg/hour), median (IQR)	8.9 (6.8-12.5)	6.9 (4.5-8.8)	0.058
Preoperative body weight (kg), median (IQR)	58.1 (52.2-68.0)	59.7 (54.0-65.0)	0.845
Maximum postoperative weight gain (%), median (IQR)	2.6 (1.2-6.3)	3.5 (1.0-6.4)	0.918
Complications (Clavien-Dindo grade ≥ IIIa) (%)	6 (13.3)	6 (54.6)	0.003b

^aP < 0.05.

^bP < 0.01.

Statistical analyses: Mann-Whitney U test for continuous variables, χ² or Fisher’s exact test for categorical variables. Minor liver resection < 3 Couinaud segments, major liver resection ≥ 3 Couinaud segments (Brisbane 2000 classification). MinLR: Minor liver resection; MajLR: Major liver resection; IQR: Interquartile range.