Vasopressin and fluid retention after liver resection: Comparison with the renin-angiotensin-aldosterone system by surgical extent and liver function

Table 2 Comparison of perioperative variables between patients with normal and impaired liver function, mean ± SD/n (%)

	NL group (n = 27)	IL group (n = 29)	P value
Age (years), median (IQR)	66 (60-74)	71 (68-77)	0.034a
Sex (men/women)	15 (55.6)/12 (44.4)	22 (75.9)/7 (24.1)	0.109
Indication of liver resection			0.003b
Colorectal liver metastasis	16 (59.3)	9 (31.0)
Hepatocellular carcinoma	3 (11.1)	17 (55.6)
Biliary tract cancer	4 (14.8)	1 (3.5)
Others	4 (14.8)	2 (6.9)
Indocyanine green retention rate at 15 minutes (%), median (IQR)	7.2 (6.2-7.8)	14.1 (11.7-18.8)	< 0.001b
Kinetic indocyanine green elimination rate constant, median (IQR)	0.175 (0.170-0.186)	0.131 (0.111-0.143)	< 0.001b
Fibrosis-4 index, median (IQR)	1.46 (1.13-2.38)	2.48 (1.37-4.35)	0.014a
Albumin-bilirubin scoring	-2.69 ± 0.08	-2.49 ± 0.08	0.082
Modified ALBI grade (1/2a/2b)	15 (55.6)/10 (37.0)/2 (7.4)	11(37.9)/8 (27.6)/10 (34.5)	0.047a
Number of complete resected Couinaud segments, median (IQR)	1 (0-2)	0 (0-2)	0.419
Laparoscopic surgery	10 (37.0)	12 (41.1)	0.740
Extrahepatic bile duct resection	2 (7.4)	2 (6.9)	0.941
Concomitant colorectal resection	2 (7.4)	1 (3.5)	0.511
Operative duration (minute), median (IQR)	297 (218-328)	288 (224-384)	0.850
Intraoperative blood loss (mL), median (IQR)	388 (100-641)	290 (83.5-523)	0.774
Intraoperative red blood cell transfusion	5 (18.5)	6 (20.7)	0.838
Intraoperative fluid balance (mL/kg/hour), median (IQR)	8.1 (6.4-12.0)	8.2 (6.6-12.4)	0.844
Preoperative body weight (kg), median (IQR)	57.7 (51.9-71.8)	59.7 (53.3-64.2)	1.000
Maximum postoperative weight gain (%), median (IQR)	2.4 (1.0-6.1)	3.1 (1.5-7.5)	0.403
Complications (Clavien-Dindo grade ≥ IIIa) (%)	4 (14.8)	8 (27.6)	0.245

^aP < 0.05.

^bP < 0.01.

Statistical analyses: Mann-Whitney U test for continuous variables, χ² or Fisher exact test for categorical variables. For normal liver group: Indocyanine green retention rate at 15 minutes (ICG_R15) < 10%, and for impaired liver group: ICG_R15 ≥ 10%. NL: Normal liver; IL: Impaired liver; IQR: Interquartile range; ALBI: Albumin-bilirubin.