Scutellaria baicalensis Georgi as a potential therapeutic drug intervention in ulcerative colitis: Mechanisms of action and clinical trials

Table 4 Clinical trials of other Huangqin-based traditional Chinese medicine formula in ulcerative colitis treatment

Treatments		Dosage of Huangqin	Number of patients	Results (overall response rate), %		Adverse events	Ref.
				Control group	Intervention group
Other Huangqin-based formula	Control group: Mesalazine enteric-coated tablets 3 g/day orally. Intervention group: Oral administration of Qinlian Lizhong decoction (huangqin 12 g, huanglian 9 g, baishao 15 g, dangshen 9 g, ganjiang 6 g, baizhu 12 g, xianhecao 15 g, shiliupi 12 g, with adjustments according to symptoms). Treatment time: 2 months	12 g	37/38	67.6	81.6	Not reported	[163]
	Control group: Mesalazine enteric-coated tablets 3 g/day orally. Intervention group: Oral administration of Qinlian Lizhong decoction (huangqin 12 g, huanglian 9 g, baishao 15 g, dangshen 9 g, ganjiang 6 g, baizhu 12 g, xianhecao 15 g, shiliupi 12 g, with adjustments according to symptoms). Treatment time: 2 months	12 g	57/58	70.17	84.48	Control group: Mild nausea and dizziness/1. Intervention group: 0	[164]
Other Huangqin-based formula plus western medicine	Control group: Oral mesalazine enteric-coated tablets 4 g/day. Intervention group: Control group treatment + compound Qinbai granules 12 g enema (in-house preparation). Treatment time: 2 months	Unknown	60/60	78.33	95.00	Not reported	[165]
	Control group: Oral mesalazine sustained-release granules 1.5 g/day. Intervention group: Control group treatment + 10 mg Qinbai granules enema (in-house preparation). Treatment time: 3 months	Unknown	36/37	72.2	91.9	Not reported	[166]
	Control group: Oral mesalazine sustained-release tablets 0.3 g/day. Intervention group: Control group treatment + Huangqin Shaoyao decoction orally (huangqi 30 g, huangqin 20 g, dangshen 20 g, shaoyao 15 g, jinyinhua 15 g, dazao 15 g, gancao 10 g, baizhu 9 g, danggui 9 g, huanglian 6 g, muxiang 6 g, adjusted according to symptoms). Treatment time: 12 weeks	20 g	49/49	77.55	91.84	Control group: Nausea and vomiting/1, abdominal distension/2, headache and fatigue/1. Intervention group: Nausea and vomiting/2, abdominal distension/1	[167]