Gene, genetics and genetic medicines in gastroenterology: Current status and its future

doi:10.3748/wjg.v32.i1.112496

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 7, 2026; 32(1): 112496
Published online Jan 7, 2026. doi: 10.3748/wjg.v32.i1.112496

Table 18 Messenger RNA therapy in disorders of gastrointestinal tract

Agent/platform	Target/indication (GIT)	Study type/phase
RNA-4157/V940 (Moderna)	Individualized neoantigen vaccine colorectal cancer	Phase 2b/3 trial undergoing
BioNTech iNeST/BNT-pipeline	Personalized or fixed mRNA cancer vaccines for CRC, pancreatic, HCC	Phase 1/2 trials
Gritstone GRANITE	Personalized neoantigen immunotherapy MSS colorectal cancer	Phase 2 trial
MSK/investigator-initiated mRNA vaccine	Personalized mRNA neoantigen vaccine pancreatic adenocarcinoma	Early phase trial
OX40 L mRNA (LNP delivery)	Immune costimulatory agonist mRNA for HCC	Preclinical

GIT: Gastrointestinal tract; LNP: Lipid nanoparticle; mRNA: Messenger RNA; CRC: Colorectal cancer; HCC: Hepatocellular carcinoma; MSS: Microsatellite stable.

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Citation: Kumar A, Sarangi Y, Kaw P. Gene, genetics and genetic medicines in gastroenterology: Current status and its future. World J Gastroenterol 2026; 32(1): 112496
URL: https://www.wjgnet.com/1007-9327/full/v32/i1/112496.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i1.112496

Kumar A, Sarangi Y, Kaw P. Gene, genetics and genetic medicines in gastroenterology: Current status and its future. World J Gastroenterol 2026; 32(1): 112496 [PMID: 41551533 DOI: 10.3748/wjg.v32.i1.112496]

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