Runchangningshen paste activates NLRP6 inflammasome-mediated autophagy to stimulate colonic mucin-2 secretion and modulates mucosal microbiota in functional constipation

doi:10.3748/wjg.v31.i9.102256

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 7, 2025; 31(9): 102256
Published online Mar 7, 2025. doi: 10.3748/wjg.v31.i9.102256

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Figure 4 Runchangningshen paste improved the inhibition effect of functional constipation on autophagy and mucin exocytosis in goblet cells. The representative picture of the ultrastructure of the goblet cells by the transmission electron microscope (× 3400 magnification). The blue area and dots indicate the mucins, the red arrows indicate the autophagosome, and the yellow arrows indicate the damaged mitochondria. FC: Functional constipation model group; HRCNSP: High dose of runchangningshen paste group; LAC: Lactulose group; LRCNSP: Low dose of runchangningshen paste group; MRCNSP: Medium dose of runchangningshen paste group; NC: Normal control group.

Citation: Liu XJ, Ye-er-tai YLY, Jia YB, Wu CH, Wang XX, Yang KM, Yao X, Ling JH. Runchangningshen paste activates NLRP6 inflammasome-mediated autophagy to stimulate colonic mucin-2 secretion and modulates mucosal microbiota in functional constipation. World J Gastroenterol 2025; 31(9): 102256
URL: https://www.wjgnet.com/1007-9327/full/v31/i9/102256.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i9.102256

Liu XJ, Ye-er-tai YLY, Jia YB, Wu CH, Wang XX, Yang KM, Yao X, Ling JH. Runchangningshen paste activates NLRP6 inflammasome-mediated autophagy to stimulate colonic mucin-2 secretion and modulates mucosal microbiota in functional constipation. World J Gastroenterol 2025; 31(9): 102256 [PMID: 40061589 DOI: 10.3748/wjg.v31.i9.102256]

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