Ras-related protein Rab24 plays a predictive role in hepatocellular carcinoma and enhanced tumor proliferation

Table 2 Overall survival of enrolled hepatocellular carcinoma patients

Variables	Cases	Overall survival months		P value
	n = 147	Median	mean ± SD
Age, years				0.153
≤ 50	78	39.0	38.0 ± 2.5
> 50	69	35.0	33.5 ± 3.1
Sex				0.297
Feale	42	47.0	38.9 ± 3.1
Male	105	34.0	34.3 ± 2.6
HBV history				0.874
Negative	43	35.0	35.5 ± 3.3
Positive	104	40.0	36.2 ± 2.5
Serum AFP, ng/mL				< 0.001
≤ 400	60	47.0	43.2 ± 2.6
> 400	87	22.0	27.7 ± 2.2
Tumor number				0.028
1	114	40.0	37.8 ± 2.3
≥ 2	33	31.0	27.5 ± 3.1
Tumor size, cm				0.002
≤ 3.0	51	48.0	43.4 ± 3.1
> 3.0	96	35.0	30.8 ± 2.3
Child-Pugh class				0.214
A	90	41.0	36.4 ± 2.2
B	48	39.0	37.1 ± 4.4
C	9	18.0	22.5 ± 5.6
BCLC stage				0.001
A	57	42.0	40.2 ± 2.7
B	46	40.0	36.6 ± 3.1
C	44	18.0	26.3 ± 4.0
Microvascular invasion				< 0.001
Absent	107	47.0	40.6 ± 2.2
Present	40	20.0	20.0 ± 2.4
Resection margin, cm				0.017
≤ 1.0	68	47.0	40.5 ± 2.5
> 1.0	79	23.0	31.2 ± 3.0
Treatment				0.003
Surgery + chemotherapy	89	42.0	39.3 ± 2.2
Surgery only	58	23.0	30.4 ± 3.6
Rab24 protein level				0.013
Low	76	47.0	40.3 ± 2.6
High	71	35.0	29.3 ± 2.3

HBV: Hepatitis B virus; AFP: Alpha-fetoprotein; BCLC: Barcelona Clinic Liver Cancer.