Clinical, pathological characteristics and long-term outcomes of hepatitis B virus related cirrhosis in pediatric observational study

Table 6 Influencing factors for the progression/remission of adult liver cirrhosis, median (interquartile range)

Variable	Progression univariate Cox [HR (95%CI)]	P value	Remission univariate Cox [HR (95%CI)]	P value
Sex	0.036 (0-77.861)	0.397	0.04 (0-1544639.826)	0.714
Age	1.045 (0.936-1.167)	0.437	0.66 (0.411-1.061)	0.086
Genotype	0.178 (0.001-43.643)	0.539	7.533 (1.388-40.875)	0.019
Biochemistry
ALT	1.011 (0.975-1.049)	0.549	0.994 (0.908-1.088)	0.889
AST	1.01 (0.983-1.038)	0.473	0.967 (0.877-1.066)	0.501
GGT	1.008 (0.995-1.021)	0.236	1.003 (0.976-1.03)	0.847
ALP	1.022 (0.995-1.049)	0.107	1.028 (0.986-1.071)	0.196
ALB	0.997 (0.88-1.128)	0.956	1.345 (0.913-1.983)	0.134
TBIL	1.055 (0.981-1.135)	0.15	1 (0.859-1.164)	0.997
DBIL	1.051 (0.936-1.181)	0.397	1.098 (0.912-1.323)	0.322
Glucose	1.239 (0.973-1.577)	0.083	0.536 (0.097-2.972)	0.476
HDL	0.382 (0.076-1.913)	0.241	1.348 (0.213-8.539)	0.751
LDL	0.483 (0.029-8.003)	0.611	0.232 (0.003-16.995)	0.505
TG	0.836 (0.078-8.926)	0.883	1.111 (0.036-34.669)	0.952
HGB	1.003 (0.977-1.03)	0.826	0.984 (0.922-1.051)	0.636
PLT	0.999 (0.991-1.006)	0.75	0.996 (0.975-1.017)	0.718
WBC	1.012 (0.926-1.107)	0.788	0.857 (0.585-1.254)	0.426
Lymphocyte	0.463 (0.108-1.979)	0.299	1.812 (0.274-11.985)	0.537
Neutrophil	1.018 (0.926-1.12)	0.708	0.789 (0.451-1.383)	0.408
HBV DNA	0.821 (0.637-1.059)	0.129	1.148 (0.916-1.439)	0.231
HBeAg	2.45 (0.585-10.262)	0.22	0.021 (0-2501.23)	0.518
AFP	1.001 (0.999-1.002)	0.534	1.001 (0.998-1.004)	0.528
PT	1.316 (0.978-1.771)	0.069	0.394 (0.079-1.95)	0.254
INR	16.58 (1.057-260.027)	0.046	0.01 (0-2444.004)	0.468
Cr	1 (0.958-1.044)	0.992	1.013 (0.927-1.107)	0.778

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transferase; ALP: Alkaline phosphatase; ALB: Albumin; TBIL: Total bilirubin; DBIL: Direct bilirubin; HDL: High density lipoprotein; LDL: Low density lipoprotein; TG: Triglyceride; HGB: Hemoglobin; PLT: Platelets; WBC: White blood cell; HBV: Hepatitis B virus; HBeAg: Hepatitis B e antigen; AFP: Alpha fetoprotein; PT: Prothrombin time; INR: International normalized ratio; Cr: Creatinine; HR: Hazard ratio; CI: Confidence interval.