Clinical, pathological characteristics and long-term outcomes of hepatitis B virus related cirrhosis in pediatric observational study

Table 5 Influencing factors for the remission of pediatric liver cirrhosis, median (interquartile range)

Variable	Univariate Cox [HR (95%CI)]	P value	Multivariate Cox [HR (95%CI)]	P value
Sex	1.743 (0.659-4.607)	0.263
Age	0.955 (0.893-1.021)	0.177
Genotype	1.367 (0.771-2.423)	0.285
Biochemistry
ALT	1.001 (0.999-1.003)	0.284
AST	1.001 (0.998-1.003)	0.587
GGT	1.006 (1.003-1.009)	0.0001	1 (0.992-1.008)	0.939
ALP	1.001 (0.997-1.004)	0.741
ALB	1.007 (0.927-1.093)	0.873
TBIL	1.008 (0.985-1.031)	0.507
DBIL	1.009 (0.976-1.042)	0.608
Glucose	0.356 (0.167-0.756)	0.007	0.159 (0.032-0.788)	0.024
HDL	2.183 (0.638-7.469)	0.213
LDL	1.592 (0.937-2.707)	0.086
TG	0.556 (0.233-1.325)	0.185
HGB	1.005 (0.978-1.033)	0.717
PLT	1.004 (0.999-1.008)	0.121
WBC	1.149 (0.992-1.33)	0.064
Lymphocyte	1.214 (0.974-1.514)	0.085
Neutrophil	1.155 (0.823-1.62)	0.404
HBV DNA	1.296 (1.046-1.605)	0.018	1.133 (0.748-1.718)	0.555
HBsAg	1.428 (1.089-1.873)	0.01	1.951 (0.954-3.993)	0.067
HBeAg	2.109 (0.638-6.973)	0.222
AFP	1.001 (1-1.001)	0.002	1.001 (1-1.002)	0.003
T lymphocyte	1 (1-1.001)	0.043	0.999 (0.998-1.001)	0.33
B lymphocyte	1 (1-1.001)	0.045	0.999 (1.001-1.003)	0.43
NK	1.003 (1.001-1.005)	0.003	1.004 (1-1.008)	0.063
CD8+	1 (1-1.001)	0.137
CD4+	1.001 (1-1.002)	0.014	1 (0.997-1.003)	0.819
CD4/CD8	1.061 (0.512-2.199)	0.874
PT	1.02 (0.801-1.299)	0.873
INR	0.905 (0.027-30.07)	0.956
Cr	0.993 (0.996-1.02)	0.603

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transferase; ALP: Alkaline phosphatase; ALB: Albumin; TBIL: Total bilirubin; DBIL: Direct bilirubin; HDL: High density lipoprotein; LDL: Low density lipoprotein; TG: Triglyceride; HGB: Hemoglobin; PLT: Platelets; WBC: White blood cell; HBV: Hepatitis B virus; HBsAg: Hepatitis B surface antigen; HBeAg: Hepatitis B e antigen; AFP: Alpha fetoprotein; NK: Natural killer; CD: Cluster of differentiation; PT: Prothrombin time; INR: International normalized ratio; Cr: Creatinine; HR: Hazard ratio; CI: Confidence interval.