Clinical, pathological characteristics and long-term outcomes of hepatitis B virus related cirrhosis in pediatric observational study

doi:10.3748/wjg.v31.i48.114049

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

World J Gastroenterol. Dec 28, 2025; 31(48): 114049
Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.114049

Table 3 Baseline characteristics of pediatric liver cirrhosis and chronic hepatitis B, median (interquartile range)/n (%)/mean ± SD

Variable	Liver cirrhosis (n = 62)	Chronic hepatitis B (n = 64)	P value
Demographics
Age (years)	11 (4-14)	10.5 (3-15)	0.7237
Sex			0.128
Male	54 (87.1)	49 (76.6)
Female	8 (12.9)	15 (23.4)
BMI (kg/m²)	16.76 (15.45-20.67)	17.28 (15.43-19.87)	0.6623
Biochemistry
ALT (U/L)	107.5 (58.5-207.25)	95 (44-176)	0.9829
AST (U/L)	110.5 (64.25-169.5)	76 (56-147)	0.6596
GGT (U/L)	70.5 (48-105)	23 (14-54)	< 0.0001
ALP (U/L)	299 (232.25-373)	273 (193-349)	0.0852
ALB (g/L)	39 (36-41.25)	40 (38-43)	0.0011
TBIL (μmol/L)	11.05 (8.1-19.15)	8.5 (6.3-11.7)	0.0277
DBIL (μmol/L)	4.7 (3.08-8.48)	3.1 (2-4.7)	0.0008
HDL-C (mmol/L)	1.15 (0.97-1.4)	1.18 (1.02 1.35)	0.7982
LDL-C (mmol/L)	2.27 (2.02-2.85)	2.28 (2.04-2.86)	0.631
TG (mmol/L)	0.94 (0.75-1.28)	0.86 (0.68-1)	0.0461
Cr (μmol/L)	48.68 ± 14.11	51.6 ± 15.41	0.2733
HGB (g/L)	127.84 ± 14.45	131.19 ± 12.05	0.1622
PLT (10⁹/L)	165 (113.5-221)	236 (206.75-284.75)	< 0.0001
WBC (10⁹/L)	6.19 (4.67-7.63)	6.56 (5.04-8.45)	0.0718
Lymphocyte (10⁹/L)	3.15 (2.12-4.26)	2.97 (2.17-4.1)	0.726
Neutrophil (10⁹/L)	3.175 (2.15-4.27)	2.5 (1.94-3.11)	0.002
log₁₀(qHBV DNA)	6.3 (4.58-7.54)	17.4 (15.41-18.62)	0.0003
log₁₀(qHBsAg)	3.11 (0-3.69)	8.956 (7.78-10.28)	< 0.0001
HBeAg(+)	48 (81.4)	60 (93.8)	0.0361
PT (seconds)	12.3 (11.55-13.35)	11.5 (10.98-12.2)	< 0.0001

BMI: Body mass index; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transferase; ALP: Alkaline phosphatase; ALB: Albumin; TBIL: Total bilirubin; DBIL: Direct bilirubin; HDL-C: High density lipoprotein cholesterol; LDL-C: Low density lipoprotein cholesterol; TG: Triglyceride; Cr: Creatinine; HGB: Hemoglobin; PLT: Platelets; WBC: White blood cell; qHBV: Quantification hepatitis B virus; qHBsAg: Quantification hepatitis B surface antigen; HBeAg: Hepatitis B e antigen; PT: Prothrombin time.

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Citation: Zhao BK, Li Y, Jiang YY, Li ML, Jiang Y, Zhu L, Guo CN, Liu SH, Chen L, Jiang LN, Niu JQ, Zhao JM. Clinical, pathological characteristics and long-term outcomes of hepatitis B virus related cirrhosis in pediatric observational study. World J Gastroenterol 2025; 31(48): 114049
URL: https://www.wjgnet.com/1007-9327/full/v31/i48/114049.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i48.114049

Zhao BK, Li Y, Jiang YY, Li ML, Jiang Y, Zhu L, Guo CN, Liu SH, Chen L, Jiang LN, Niu JQ, Zhao JM. Clinical, pathological characteristics and long-term outcomes of hepatitis B virus related cirrhosis in pediatric observational study. World J Gastroenterol 2025; 31(48): 114049 [PMID: 41480325 DOI: 10.3748/wjg.v31.i48.114049]

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