Clinical, pathological characteristics and long-term outcomes of hepatitis B virus related cirrhosis in pediatric observational study

Table 1 Baseline characteristics of pediatric liver cirrhosis, median (interquartile range)/n (%)/mean ± SD

Variable	Total (N = 62)
Demographics
Age (years)	11 (4-14)
Male	54 (87.1)
Female	8 (12.9)
BMI (kg/m2)	16.76 (15.45-20.67)
Comorbidity
Hepatic encephalopathy	0 (0)
Ascites	4 (6.5)
Gastrointestinal bleeding	0 (0)
No comorbidity	58 (93.5)
Presenting symptoms of cirrhosis
Asymptomatic	48 (77.4)
Fatigue	3 (4.8)
Aberration	4 (6.5)
Jaundice	6 (9.7)
Discomfort in the liver area	2 (3.2)
Bleeding points on the chest and abdomen	1 (1.6)
Repeated epistaxis	1 (1.6)
AFP progressively increases	1 (1.6)
Antiviral therapy before LC	8 (12.9)
Genotype
Unknown	14 (22.6)
B	5 (8.1)
C	43 (69.4)
Biochemistry
ALT (U/L)	107.5 (58.5-207.25)
AST (U/L)	110.5 (64.25-169.5)
GGT (U/L)	70.5 (48-105)
ALP (U/L)	299 (232.25-373)
ALB (g/L)	39 (36-41.25)
TBIL (μmol/L)	11.05 (8.1-19.15)
DBIL (μmol/L)	4.7 (3.08-8.48)
Glucose (mmol/L)	4.5 (4.08-4.89)
HDL-C (mmol/L)	1.15 (0.97-1.4)
LDL-C (mmol/L)	2.27 (2.02-2.85)
TG (mmol/L)	0.94 (0.75-1.28)
Cr (μmol/L)	48.68 ± 14.11
HGB (g/L)	127.84 ± 14.45
PLT (109/L)	165 (113.5-221)
WBC (109/L)	6.19 (4.67-7.63)
Lymphocyte (109/L)	3.15 (2.12-4.26)
Neutrophil (109/L)	3.175 (2.15-4.27)
log10(qHBV DNA)	6.3 (4.58-7.54)
log10(qHBsAg)	3.11 (0-3.69)
HBeAg(+)	48 (81.4)
Child-Pugh score	5 (5-6)
PELD/MELD score	3.5 (0.75-8)
AFP (ng/mL)	51 (13.73-255)
T lymphocyte	2060.62 ± 1121.46
B lymphocyte	599.5 (437-940)
NK	183.5 (113-327.25)
CD8+	718 (502.25-1012)
CD4+	1003.5 (722.25-1422.85)
CD4/CD8	1.44 (1.11-1.81)
PT (seconds)	12.3 (11.55-13.35)
INR	1.06 (0.99-1.14)

BMI: Body mass index; LC: Liver cirrhosis; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transferase; ALP: Alkaline phosphatase; ALB: Albumin; TBIL: Total bilirubin; DBIL: Direct bilirubin; HDL-C: High density lipoprotein cholesterol; LDL-C: Low density lipoprotein cholesterol; TG: Triglyceride; Cr: Creatinine; HGB: Hemoglobin; PLT: Platelets; WBC: White blood cell; qHBV: Quantification hepatitis B virus; qHBsAg: Quantification hepatitis B surface antigen; HBeAg: Hepatitis B e antigen; PELD: Pediatric end-stage liver disease model; MELD: Model for end-stage liver disease; AFP: Alpha fetoprotein; NK: Natural killer; CD: Cluster of differentiation; PT: Prothrombin time; INR: International normalized ratio.