AADN score: Predicting response to transarterial chemoembolization, sintilimab and lenvatinib in patients with hepatocellular carcinoma

doi:10.3748/wjg.v31.i48.113856

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. Dec 28, 2025; 31(48): 113856
Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.113856

Table 3 Multivariable Cox regression analyses of overall survival in the training cohort

Variable	β estimate (95%CI)	HR (95%CI)	P value
PVTT (present vs absent)		1.005 (0.481-2.099)	0.844
Child stage (B vs A)		0.857 (0.400-1.835)	0.481
AFP, ng/mL (> 100 vs ≤ 100)	0.947 (0.229-1.665)	2.579 (1.258-5.285)	0.010
ALP, U/L (> 120 vs ≤ 120)	0.804 (0.120-1.149)	2.234 (1.127-4.430)	0.021
DBIL, μmol/L (> 7.3 vs ≤ 7.3)	1.075 (0.297-1.853)	2.931 (1.346-6.382)	0.007
NLR (> 2.5 vs ≤ 2.5)	1.140 (0.325-1.955)	3.127 (1.384-7.063)	0.006

PVTT: Portal vein tumor thrombus; AFP: Alpha-fetoprotein; ALP: Alkaline phosphatase; DBIL: Direct bilirubin; NLR: Neutrophil to lymphocyte ratio; HR: Hazard ratio; CI: Confidence interval.

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Citation: Zhang X, Liao MJ, Ren LY, Qin WY, Mu SW, She SP, Fei R, Cong X, Zhou YP, Chen DB, Chen HS. AADN score: Predicting response to transarterial chemoembolization, sintilimab and lenvatinib in patients with hepatocellular carcinoma. World J Gastroenterol 2025; 31(48): 113856
URL: https://www.wjgnet.com/1007-9327/full/v31/i48/113856.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i48.113856

Zhang X, Liao MJ, Ren LY, Qin WY, Mu SW, She SP, Fei R, Cong X, Zhou YP, Chen DB, Chen HS. AADN score: Predicting response to transarterial chemoembolization, sintilimab and lenvatinib in patients with hepatocellular carcinoma. World J Gastroenterol 2025; 31(48): 113856 [PMID: 41480328 DOI: 10.3748/wjg.v31.i48.113856]

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