Exploring exercise modalities and their impact on inflammatory bowel disease: A systematic review of rodent colitis models

Table 1 Characteristics of included studies

Ref.	Year	Experimental subjects	Modeling method	Exercise type	Exercise parameters
Kasimay et al[15]	2006	Sprague–Dawley rats	4% acetic acid, 1 mL, intracolonic administration	FTR	7 m/minute, 30 minutes/day, 3 days/week, total 6 weeks
Saxena et al[16]	2012	Adiponectin KO and WT C57BL/6 mice	2% DSS, drinking water, 5 days	FTR	18 m/minute, 55 minutes/day, 5 days/week, total 4 weeks
Cook et al[17]	2013	C57Bl/6 mice	2% DSS, drinking water, 5 days	FTR	8-12 m/minute, 40 minutes/day, 5 days/week, total 6 weeks, inclination of 5°
Bilski et al[18]	2015	Wistar rats	TNBS, 10 mg/kg in 50% ethanol, 250 μL, intracolonic administration	FTR	20 m/minute, 30 minutes/day, 5 days/week, total 6 weeks
Bilski et al[19]	2019	C57BL/6 mice	TNBS, 100 μg/g in 40% ethanol, 175 μL, intracolonic administration	FTR	7.2 m/minute, 30 minutes/day, 7 days/week, total 6 weeks
Qonitatillah et al[20]	2020	BALB/c mice	λ-carrageenan, 20 mg/L, drinking water, 6 weeks	FTR	7 m/minute, 30 minutes/day, 3 days/week, total 6 weeks
Van Mechelen et al[21]	2022	C57BL/6 mice	Acute colitis: 2% DSS, drinking water, 7 days; chronic colitis: Three cycles of 7 days DSS and 14 days recovery	FTR	11 m/minute, 60 minutes/day, 7 days/week, total 3 weeks, inclination of 5°
Hao et al[22]	2024	C57BL/6J mice	2% DSS, drinking water, 7 days	FTR	10 m/minute, 5 minutes × 10 bouts with 2 minutes of rest, 5 days/week, total 12 weeks
Jin et al[23]	2024	C57BL/6 mice	2% DSS, drinking water, 7 days	FTR	5 m/minute × 10 minutes, 8 m/minute × 50 minutes, total 14 days
Wojcik-Grzybek et al[24]	2024	C57BL/6 mice	TNBS, 4 mg in 50% ethanol, 175 μL, intracolonic administration	FTR	6 m/minute, 10 minutes/day, 5 days/week, total 6 weeks
Cook et al[17]	2013	C57BL/6 mice	2% DSS, drinking water, 5 days	VWR	30 days
Szalai et al[25]	2014	Wistar rats	TNBS, 10 mg in 0.25 mL of 50% ethanol, intracolonic administration	VWR	6 weeks
Liu et al[26]	2015	C57BL/6 mice	2% DSS, drinking water, 5 days	VWR	30 days
Mazur-Bialy et al[27]	2017	C57BL/6 mice	TNBS, 100 μg/g in 40% ethanol, 250 μL, intracolonic administration	VWR	6 weeks
Maillard et al[28]	2019	CEABAC10 transgenic mice	Bacterial exposure	VWR	12 weeks
Estaki et al[29]	2020	Muc2-/- and WT C57BL/6 mice	Muc2-/- idiopathic colitis	VWR	6 weeks
Wojcik-Grzybek et al[30]	2022	C57BL/6 mice	TNBS, 4 mg in 50% ethanol, 175 μL, intracolonic administration	VWR	7 weeks
Kolahi et al[31]	2023	C57BL/6 mice	1.5% DSS, drinking water, 7 days	Swimming	15-20 minutes/day, 5 days/week, for 6 weeks
Özbeyli et al[32]	2016	Sprague-Dawley rats	4% acetic acid, 1 mL, intracolonic administration	Swimming	30 minutes/day, 3 days/week, 5 weeks
de Oliveira Santos et al[33]	2021	Wistar rats	4% acetic acid, 1 mL, intracolonic administration	Swimming	1 hour/day, 5 days/week, 8 weeks
Özbeyli et al[32]	2016	Sprague-Dawley rats	4% acetic acid, 1 mL, intracolonic administration	Climb	Rats climbed vertical ladder with a load, 8 repeats 3 sets, 3 days/week, total 5 weeks
de Oliveira Santos et al[33]	2021	Wistar rats	4% acetic acid, 1 mL, intracolonic administration	Jump	Rats jump in the water with a load, 4 × 10 repetitions, 60 minutes/day, 5 days/week, total 8 weeks with progressive overload

KO: Knockout; WT: Wild-type; DSS: Dextran sulfate sodium; TNBS: Trinitro-benzene-sulfonic acid; FTR: Forced treadmill running; VWR: Voluntary wheel running.