Serum uric acid-to-high-density lipoprotein cholesterol ratio and cardiovascular risk in Asian patients with metabolic dysfunction-associated steatotic liver disease

doi:10.3748/wjg.v31.i48.112972

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2025; 31(48): 112972
Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.112972

Table 2 Performance of serum uric acid to high-density lipoprotein cholesterol ratio and conventional biomarkers in predicting intermediate/high cardiovascular risk by Framingham risk score, %

Variables	AUC	95%CI	Sensitivity	Specificity	Optimal cutoff	P value
UHR	0.655	(0.635, 0.674)	61.4	62.5	291.739	< 0.0001
SUA	0.626	(0.607, 0.646)	62.6	56.7	350.650	< 0.0001
HDL-C	0.617	(0.598, 0.637)	55.6	64.8	1.195	< 0.0001
TG	0.597	(0.577, 0.617)	52.9	61.1	1.815	< 0.0001

AUC: Area under the curve; CI: Confidence interval; UHR: Uric acid to high-density lipoprotein cholesterol ratio; SUA: Serum uric acid; HDL-C: High-density lipoprotein cholesterol; TG: Triglycerides.

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Citation: Wang Y, Ma GH, Qu MY, Xu QS, Huang HX. Serum uric acid-to-high-density lipoprotein cholesterol ratio and cardiovascular risk in Asian patients with metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2025; 31(48): 112972
URL: https://www.wjgnet.com/1007-9327/full/v31/i48/112972.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i48.112972

Wang Y, Ma GH, Qu MY, Xu QS, Huang HX. Serum uric acid-to-high-density lipoprotein cholesterol ratio and cardiovascular risk in Asian patients with metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2025; 31(48): 112972 [PMID: 41480320 DOI: 10.3748/wjg.v31.i48.112972]

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