Combined metabolomic and metagenomic analysis reveals inflammatory bowel disease diversity in pediatric and adult patients

doi:10.3748/wjg.v31.i48.112653

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2025; 31(48): 112653
Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.112653

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Figure 10 Spearman correlation between metabolite levels and relative abundance of microbial species. P < 0.05. A: Crohn’s disease; B: Ulcerative colitis; C: Shannon’s index diversity of metabolites in ulcerative colitis and Crohn’s disease groups. UC: Ulcerative colitis; CD: Crohn’s disease.

Citation: Zakharzhevskaya NB, Erdes SI, Belousova EA, Samolygo IS, Manina MA, Kondrashova PV, Lomakina EY, Kardonsky DA, Vorobyeva EA, Shagaleeva OY, Silantyev AA, Kazakova VD, Kashatnikova DA, Kalachnuk TN, Kolesnikova IV, Chaplin AV, Markelova MI, Grigoryeva TV, Olekhnovich EI, Veselovsky VA, Morozov MD, Zoruk PY, Boldyreva DI, Vanyushkina AA, Efimov BA. Combined metabolomic and metagenomic analysis reveals inflammatory bowel disease diversity in pediatric and adult patients. World J Gastroenterol 2025; 31(48): 112653
URL: https://www.wjgnet.com/1007-9327/full/v31/i48/112653.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i48.112653

Zakharzhevskaya NB, Erdes SI, Belousova EA, Samolygo IS, Manina MA, Kondrashova PV, Lomakina EY, Kardonsky DA, Vorobyeva EA, Shagaleeva OY, Silantyev AA, Kazakova VD, Kashatnikova DA, Kalachnuk TN, Kolesnikova IV, Chaplin AV, Markelova MI, Grigoryeva TV, Olekhnovich EI, Veselovsky VA, Morozov MD, Zoruk PY, Boldyreva DI, Vanyushkina AA, Efimov BA. Combined metabolomic and metagenomic analysis reveals inflammatory bowel disease diversity in pediatric and adult patients. World J Gastroenterol 2025; 31(48): 112653 [PMID: 41480317 DOI: 10.3748/wjg.v31.i48.112653]

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