Combined metabolomic and metagenomic analysis reveals inflammatory bowel disease diversity in pediatric and adult patients

Figure 4 Total headspace-gas chromatography-mass spectrometry data obtained for the inflammatory bowel disease group of pediatric and adult patients. A and B: Principal component analysis and Orthogonal Partial Least Squares Discriminant Analysis data represent two independent groups of samples [inflammatory bowel disease (IBD)-kids, IBD-adults] according to the relative concentration of all detected volatile compounds; C: Comparison of volatile organic compound composition for two independent groups of samples (IBD-kids, IBD-adults). Relative concentrations in the vapor phase were used; D: The nonparametric Mann-Whitney test was used for the primary comparisons between groups. Statistical significance was determined by a two-sided P-value of less than 0.05. False discovery rate correction was also applied. UC: Ulcerative colitis; CD: Crohn’s disease; IBD: Inflammatory bowel disease.