Combined metabolomic and metagenomic analysis reveals inflammatory bowel disease diversity in pediatric and adult patients

Figure 3 Total headspace-gas chromatography-mass spectrometry data obtained for ulcerative colitis and Crohn’s disease and control groups of pediatric patients. A: Comparison of the volatile organic compound composition of stable detected metabolites for two independent groups of samples (inflammatory bowel disease kids and control kids). Relative concentrations in the vapor phase were used; B: The nonparametric Mann-Whitney test was used for the primary comparisons between groups, inflammatory bowel disease kids, and Control kids. Statistical significance was determined by a two-sided P-value of less than 0.05. False discovery rate correction was also applied; C: Comparison of the volatile organic compound composition of stable detected metabolites for three independent groups of samples (ulcerative colitis kids, Crohn’s disease kids, and control kids). Relative concentrations in the vapor phase were used; D: The nonparametric Mann-Whitney test was used for the primary comparisons between groups: Ulcerative colitis kids, Crohn’s disease kids, and control kids. Statistical significance was determined by a two-sided P-value of less than 0.05. False discovery rate correction was also applied. UC: Ulcerative colitis; CD: Crohn’s disease; IBD: Inflammatory bowel disease.