Combined metabolomic and metagenomic analysis reveals inflammatory bowel disease diversity in pediatric and adult patients

Figure 1 Total headspace-gas chromatography-mass spectrometry data obtained for inflammatory bowel disease and control groups of pediatric patients. A and B: Principal component analysis and Orthogonal Partial Least Squares Discriminant Analysis data represent two independent groups of samples [inflammatory bowel disease (IBD) kids and control kids] according to the relative concentration of all detected volatile compounds; C and D: Principal component analysis and Orthogonal Partial Least Squares Discriminant Analysis data represent two independent groups of samples (IBD kids and control kids) according to the relative concentration of stable detected volatile compounds; E: Comparison of volatile organic compound composition for two independent groups of samples (IBD kids and control kids). Relative concentrations in the vapor phase were used. PCA: Principal component analysis; IBD: Inflammatory bowel disease; OPLS-DA: Orthogonal Partial Least Squares Discriminant Analysis.