Sphinganine inhibits macrophage polarization and protects against sepsis-induced intestinal injury

Figure 4 Sphinganine targets the toll like receptor 2/nuclear factor kappa-B axis to inhibit macrophage polarization. A-E: Representative Western blot images and quantitative analysis of phosphorylated p65 and total p65 protein expression in colon tissues from different groups of mice (n = 3 per group). Data are presented as mean ± SEM. ^cP < 0.001. TLR2: Toll like receptor 2; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; CLP: Cecal ligation and puncture; FSL-1: Fibroblast-stimulating lipopeptide-1; ns: Not significant; p-p65: Phosphorylated p65.