Molecular links between inflammatory bowel disease and Alzheimer’s disease through immune signaling and inflammatory pathways

doi:10.3748/wjg.v31.i48.111301

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2025; 31(48): 111301
Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.111301

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Figure 3 Gut-brain axis comparison between healthy individuals and Alzheimer's disease patients with inflammatory bowel disease. Healthy individuals maintain intact blood-brain barrier (BBB), balanced neurotransmitters, and diverse gut microbiota, while Alzheimer’s disease patients with inflammatory bowel disease exhibit disrupted BBB, neuroinflammation, dysbiosis, and reduced short-chain fatty acids. SCFAs: Short-chain fatty acids; GABA: γ-aminobutyric acid.

Citation: Durairajan SSK, Singh AK, Sulaiman SM, Patnaik S, Krishnamoorthi S, Iyaswamy A, Vellingiri B, Yang CB, Williams LL. Molecular links between inflammatory bowel disease and Alzheimer’s disease through immune signaling and inflammatory pathways. World J Gastroenterol 2025; 31(48): 111301
URL: https://www.wjgnet.com/1007-9327/full/v31/i48/111301.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i48.111301

Durairajan SSK, Singh AK, Sulaiman SM, Patnaik S, Krishnamoorthi S, Iyaswamy A, Vellingiri B, Yang CB, Williams LL. Molecular links between inflammatory bowel disease and Alzheimer’s disease through immune signaling and inflammatory pathways. World J Gastroenterol 2025; 31(48): 111301 [PMID: 41480321 DOI: 10.3748/wjg.v31.i48.111301]

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