Molecular links between inflammatory bowel disease and Alzheimer’s disease through immune signaling and inflammatory pathways

doi:10.3748/wjg.v31.i48.111301

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2025; 31(48): 111301
Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.111301

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Figure 1 This schematic timeline illustrates the progression of Alzheimer’s disease-related pathologies in the central nervous system and gastrointestinal tracts of APPNL-G-F and amyloid precursor protein/PS1 transgenic mouse models. APP: Amyloid precursor protein; CNS: Central nervous system; GI: Gastrointestinal; Aβ: Amyloid-β.

Citation: Durairajan SSK, Singh AK, Sulaiman SM, Patnaik S, Krishnamoorthi S, Iyaswamy A, Vellingiri B, Yang CB, Williams LL. Molecular links between inflammatory bowel disease and Alzheimer’s disease through immune signaling and inflammatory pathways. World J Gastroenterol 2025; 31(48): 111301
URL: https://www.wjgnet.com/1007-9327/full/v31/i48/111301.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i48.111301

Durairajan SSK, Singh AK, Sulaiman SM, Patnaik S, Krishnamoorthi S, Iyaswamy A, Vellingiri B, Yang CB, Williams LL. Molecular links between inflammatory bowel disease and Alzheimer’s disease through immune signaling and inflammatory pathways. World J Gastroenterol 2025; 31(48): 111301 [PMID: 41480321 DOI: 10.3748/wjg.v31.i48.111301]

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