Interpretable machine learning model for early complication prediction after split liver transplantation

Table 2 Logistic regression evaluation of factors associated with early postoperative complications following split liver transplantation

Characteristics1	Univariable		Multivariable
	OR (95%CI)	P value	OR (95%CI)	P value
Recipient age (years)	1.012 (0.970-1.052)	0.544
Gender (female)	1.077 (0.470-2.436)	0.859
BMI (kg/m2)	1.048 (0.950-1.159)	0.349
Blood pressure (yes)	0.752 (0.190-2.440)	0.650
CHD (yes)	1.931 (0.660-5.559)	0.219
Diabetes (yes)	1.048 (0.380-2.711)	0.924
MELD scores2	1.074 (1.020-1.137)	0.012	1.104 (1.027-1.186)	0.008
Child-Pugh class2
A2	Reference
B2	5.600 (1.491-21.036)	0.011
C2	5.778 (1.140-23.342)	0.014
Transplant indication
Hepatitis (B and C)	Reference
Tumor	0.882 (0.360-2.161)	0.784
Alcohol liver disease	0.403 (0.074-2.186)	0.292
Autoimmune disease	0.176 (0.036-0.870)	0.033
polycystic liver	1.412 (0.082-24.178)	0.812
GRWR (%)	1.345 (0.540-3.384)	0.526
Donor age (years)	1.019 (0.980-1.061)	0.331
ABO incompatibility (yes)	1.314 (0.210-8.233)	0.770
Anhepatic phase	1.023 (0.990-1.059)	0.179
Blood loss2 (mL)	1.001 (1.000-1.001)	0.002	1.001 (1.000-1.001)	0.043
Operation time2 (minutes)	1.003 (1.000-1.007)	0.039	1.002 (0.998-1.006)	0.271
CIT (minutes)	1.003 (1.000-1.008)	0.140
WIT (seconds)	1.005 (1.000-1.014)	0.261
IV PL2 (yes)	0.242 (0.080-0.617)	0.005	0.226 (0.070-0.727)	0.013
LnSII2	1.971 (1.290-3.165)	0.003	1.729 (1.028-2.907)	0.039
AFR2	0.942 (0.890-0.986)	0.024	0.942 (0.879-1.010)	0.093
HB (g/L)	0.985 (0.970-1.003)	0.111
ALT (U/L)	1.000 (1.000-1.004)	0.914
AST (U/L)	1.000 (1.000-1.003)	0.706
ALP (U/L)	1.002 (1.000-1.006)	0.240
GGT (U/L)	1.003 (1.000-1.007)	0.200
APTT (seconds)	1.020 (0.990-1.051)	0.171

¹The associations of early postoperative complications with clinical characteristics were assessed by univariate and multivariable logistic regression.

²P values statistical significance.

OR: Odds ratio; CI: Confidence interval; BMI: Body mass index; CHD: Coronary heart disease; MELD: Model for end-stage liver disease; GRWR: Graft-to-recipient weight ratio; CIT: Cold ischemia time; WIT: Warm ischemia time; IV PL: Partial lobectomy of segment IV; LnSII: Log-transformed systemic immune inflammatory index; AFR: Albumin-to-fibrinogen ratio; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transferase; APTT: Activated partial thromboplastin time.