Comparison of the prognostic value of different inflammation-based scores in patients with hepatocellular carcinoma after Lenvatinib therapy

Table 3 Univariate and multivariate Cox regression analyses of risk factors for overall survival

Variables	Univariate			Multivariate
	HR	95%CI	P value	HR	95%CI	P value
Age, year (>/≤ 50)	0.821	0.325-2.075	0.677
Gender (female/male)	0.273	0.036-2.057	0.207
Largest tumor size, cm (>/≤ 10)	1.982	0.702-5.6	0.197
Tumor number (> 1/1)	8.086	1.073-60.944	0.043
Macrovascular invasion (yes/no)	10.399	1.380-78.368	0.023	10.594	1.394-80.525	0.023
Lymph node metastasis (yes/no)	1.383	0.490-3.908	0.540
Metastasis (yes/no)	4.393	1.47-13.128	0.008	4.431	1.395-14.073	0.012
PT, s (>/≤ 13.5)	1.098	0.251-4.799	0.901
HBsAg, IU/mL (>/≤ 0.05)	2.386	0.317-17.942	0.398
ALB, g/L (>/≤ 35)	1.322	0.382-4.569	0.659
ALT, U/L (>/≤ 50)	1.118	0.443-2.821	0.813
APOB, g/L (>/≤ 1.10)	0.822	0.308-2.196	0.697
APOA1, g/L (>/≤ 1.60)	1.166	0.267-5.094	0.838
AST, U/L (>/≤ 40)	27.327	0.145-5143.118	0.216
CHO, mmol/L (>/≤ 5.69)	1.038	0.402-2.683	0.938
CRE, µmol/L (>/≤ 97)	1.969	0.452-8.573	0.367
CRP, mg/L (>/≤ 7.9)	4.494	1.031-19.585	0.045
GGT, U/L (>/≤ 60)	27.116	0.115-6392.722	0.236
TBIL, µmol/L (>/≤ 20.5)	2.628	1.027-6.727	0.044
MO, × 109/L (>/≤ 0.6)	1.204	0.477-3.042	0.694
NE, × 109/L (>/≤ 6.3)	1.084	0.386-3.047	0.878
WBC, × 109/L (>/≤ 9.5)	1.067	0.351-3.246	0.909
PLR (>/≤ 269.51)	2.843	1.009-8.008	0.048
NLR (>/≤ 3.28)	3.268	1.161-9.195	0.025
LCR (>/≤ 3185.19)	7.315	0.971-55.084	0.053
LMR (>/≤ 2.41)	0.276	0.105-0.725	0.009
SII (>/≤ 768.03)	2.888	1.021-8.166	0.046
CAR (>/≤ 0.19)	2.708	0.782-9.374	0.116
PNI (>/≤ 49.1)	3.924	1.384-11.124	0.01	4.097	1.405-11.944	0.01

P < 0.05 is statistically significant in both univariate and multivariate analyses. PT: Prothrombin time; HBsAg: Hepatitis B surface antigen; ALB: Albumin; ALT: Alanine aminotransferase; APOB: Apolipoprotein B; APOA1: Apolipoprotein A1; AST: Aspartate aminotransferase; CHO: Cholesterol; CRE: Creatinine; CRP: C-reactive protein; GGT: Γ-Glutamyl transferase; TBIL: Total bilirubin; PLR: Platelet-to-lymphocyte ratio; NLR: Neutrophil-to-lymphocyte ratio; LCR: Lymphocyte-to-C-reactive protein ratio; LMR: Lymphocyte-to-monocyte ratio; SII: Systemic immune-inflammation index; CAR: C-reactive protein-to-albumin ratio; PNI: Prognostic nutritional index; MO: Monocyte; NE: Neutrophil; WBC: White blood cell.