Saffron and Calculus bovis combination exerts anti-hepatic fibrotic effect in liver fibrosis rats via the mitogen-activated protein kinases pathway

doi:10.3748/wjg.v31.i47.113496

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 21, 2025; 31(47): 113496
Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.113496

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Figure 6 Graphical abstract. Saf: Saffron; Cal b: Calculus bovis; PPI: Protein-protein interactions; GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes; ERK: Extracellular signal-regulated kinase; MAPK: Mitogen-activated protein kinase; JNK: C-Jun N-terminal kinases; TGF-β: Transforming growth factor-β; SMAD3: Mothers against decapentaplegic homolog 3.

Citation: Sun SN, Wang K, Xu Y, Ye F, Xia WN, Wang ZW, Liu F, He ZX, Chen M, Du QH. Saffron and Calculus bovis combination exerts anti-hepatic fibrotic effect in liver fibrosis rats via the mitogen-activated protein kinases pathway. World J Gastroenterol 2025; 31(47): 113496
URL: https://www.wjgnet.com/1007-9327/full/v31/i47/113496.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i47.113496

Sun SN, Wang K, Xu Y, Ye F, Xia WN, Wang ZW, Liu F, He ZX, Chen M, Du QH. Saffron and Calculus bovis combination exerts anti-hepatic fibrotic effect in liver fibrosis rats via the mitogen-activated protein kinases pathway. World J Gastroenterol 2025; 31(47): 113496 [PMID: 41479754 DOI: 10.3748/wjg.v31.i47.113496]

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