Application of stem cells in the precise diagnosis and treatment of liver diseases

doi:10.3748/wjg.v31.i46.114415

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 14, 2025; 31(46): 114415
Published online Dec 14, 2025. doi: 10.3748/wjg.v31.i46.114415

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Figure 2 Stem cell-based liver organoids. Illustration image shows the major subtypes of stem cell-based liver organoids and the corresponding biomarkers. ALB: Albumin; HNF4A: Hepatocyte nuclear factor 4 alpha; HNF1B: Hepatocyte nuclear factor 1 beta; KRT7: Keratin 7; KRT19: Keratin 19; AFP: Alpha-fetoprotein; A1AT: Alpha-1-antitrypsin; CEBPA: CCAAT/enhancer binding protein alpha; CYP: Cytochrome P450; CK7: Cytokeratin 7; STAB2: Stabilin 2; LYVE1: Lymphatic vessel endothelial hyaluronan receptor 1; CK18: Cytokeratin 18; FCGR2B: Fc gamma receptor IIb; ADRA1B: Alpha-1B adrenergic receptor; TBX3: T-box transcription factor 3; WT1: Wilms tumor 1; ASGR1: Asialoglycoprotein receptor 1; ASGR2: Asialoglycoprotein receptor 2; SERPINA1: Serpin family a member 1; TTR: Transthyretin; TDO2: Tryptophan 2,3-dioxygenase; COL1A1: Collagen type I alpha 1 chain; TIMP1: Tissue inhibitor of metalloproteinases 1; KRT17: Keratin 17; TACSTD2: Tumor-associated calcium signal transducer 2.

Citation: Wang YX, Ren YN, Zhang SS, Sun S, Xu MY, Wei T, Zhang LS. Application of stem cells in the precise diagnosis and treatment of liver diseases. World J Gastroenterol 2025; 31(46): 114415
URL: https://www.wjgnet.com/1007-9327/full/v31/i46/114415.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i46.114415

Wang YX, Ren YN, Zhang SS, Sun S, Xu MY, Wei T, Zhang LS. Application of stem cells in the precise diagnosis and treatment of liver diseases. World J Gastroenterol 2025; 31(46): 114415 [PMID: 41479645 DOI: 10.3748/wjg.v31.i46.114415]

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