Application of stem cells in the precise diagnosis and treatment of liver diseases

Table 4 Clinical trials of stem cell-based observational and interventional studies for liver diseases

NCT No.	Study title	Cell types	Study status	Condition	Phase	Enrollment	Study type	Location
NCT00953693	“Patient Specific Induced Pluripotency Stem Cells (PSiPS)”	hiPSCs	Completed	Liver insufficiency	N/A	15	Observational	Iran
NCT01591200	“Dose Finding Study to Assess Safety and Efficacy of Stem Cells in Liver Cirrhosis”	MSCs	Completed	Alcoholic liver cirrhosis	Phase 2	40	Interventional	India
NCT01429038	“MSCs After Renal or Liver Transplantation”	MSCs	Completed	Liver failure	Phase 1/2	40	Interventional	Belgium
NCT00655707	“A Phase I/II Safety and Tolerability Dose Escalation Study of Autologous Stem Cells to Patients With Liver Insufficiency”	Adult stem cells	Completed	Liver insufficiency	Phase 1/2	5	Interventional	United Kingdom
NCT02089919	“Cancer Stem Cells Vaccine Therapy in Treating Hepatocellular Cancer Patients”	Cancer stem cells	Completed	HCC	Phase 1/2	40	Interventional	China
NCT00147043	“Adult Stem Cell Therapy in Liver Insufficiency”	Adult stem cells	Completed	Liver cirrhosis	N/A	5	Interventional	United Kingdom
NCT04243681	“Combination of Autologous MSC and HSC Infusion in Patients With Decompensated Cirrhosis”	MSCs + hematopoetic stem cells	Completed	Decompensated liver cirrhosis	Phase 4	5	Interventional	India
NCT01333228	“Evaluate Safety and Efficacy of Autologous Bone Marrow-derived Endothelial Progenitor Cells in Advanced Liver Cirrhosis”	BM-EPCs	Completed	Liver cirrhosis	Phase 1/2	14	Interventional	Spain
NCT05331872	“Umbilical Cord-derived MSC Infusion in the Management of Adult Liver Cirrhosis”	UC-MSCs	Completed	Liver cirrhosis	Phase 1	20	Interventional	Vietnam
NCT00420134	“Improvement of Liver Function in Liver Cirrhosis Patients After Autologous MSC Injection: A Phase I-II Clinical Trial”	Autologous MSCs	Completed	Liver cirrhosis	Phase 1/2	30	Interventional	Iran
NCT01454336	“Transplantation of Autologous MSC in Decompensated Cirrhotic Patients With Pioglitazone”	Autologous MSCs	Completed	Decompensated liver cirrhosis	Phase 1	3	Interventional	Iran
NCT02557724	“Mobilization of MSCs During Liver Transplantation”	MSCs	Completed	Liver failure, HCC	N/A	35	Observational	United States
NCT01875081	“REVIVE (Randomized Exploratory Clinical Trial to Evaluate the Safety and Effectiveness of Stem Cell Product in Alcoholic Liver Cirrhosis Patient)”	Stem cells	Completed	Alcoholic liver cirrhosis	Phase 2	72	Interventional	South Korea
NCT01013194	“Human Fetal Liver Cell Transplantation in Chronic Liver Failure”	Fetal liver cells	Completed	Liver cirrhosis	Phase 1/2	25	Interventional	Italy
NCT02297867	“Clinical Trial Study About Human Adipose-Derived Stem Cells in the Liver Cirrhosis”	ASCs	Completed	Liver cirrhosis	Phase 1	6	Interventional	China
NCT01378182	“Efficacy of In vitro Expanded Bone Marrow Derived Allogeneic MSC Transplantation Via Portal Vein or Hepatic Artery or Peripheral Vein in Patients With Wilson Cirrhosis”	BM-MSCs	Completed	Wilson’s disease	NA	10	Interventional	Turkey
NCT01120925	“Autologous Bone Marrow Derived Stem Cells in Decompensated Cirrhotic Patients”	BM-MSCs	Completed	Decompensated liver cirrhosis	Phase 1/2	30	Interventional	Iran
NCT01220492	“Umbilical Cord MSCs for Patients With Liver Cirrhosis”	UC-MSCs	Completed	Liver cirrhosis	Phase 1/2	266	Interventional	China
NCT01342250	“Human Umbilical Cord MSCs Transplantation for Patients With Decompensated Liver Cirrhosis”	UC-MSCs	Completed	Liver cirrhosis	Phase 1/2	20	Interventional	China
NCT03468699	“Autologous Bone Marrow Mononuclear Stem Cell for Children Suffering From Liver Cirrhosis Due to Biliary Atresia”	BM-MSCs	Completed	Liver fibrosis (biliary atresia)	Phase 2	17	Interventional	Vietnam
NCT04522869	“Umbilical Cord Derived MSC (UC -MSC) Transplantation for Children Suffering From Biliary Atresia”	UC-MSCs	Completed	Primary biliary cirrhosis	Phase 1/2	20	Interventional	Vietnam
NCT01625351	“A Study of CD45RA+ Depleted Haploidentical Stem Cell Transplantation in Children With Relapsed or Refractory Solid Tumors and Lymphomas”	Hematopoetic stem cells	Completed	Hepatic tumor	Phase 1	23	Interventional	United States
NCT00003966	“Defibrotide in Treating Patients With Liver Damage Following Peripheral Stem Cell Transplantation”	Peripheral stem cells	Completed	Veno-occlusive disease	Phase 2	151	Interventional	United States
NCT03132337	“Sinusoidal Obstruction Syndrome for Stem Cell Transplant Patients Biomarker Study”	Stem cells	Completed	Sinusoidal obstruction syndrome	N/A	80	Observational	United States
NCT03963921	“Safety and Tolerability of HepaStem in Patients With Cirrhotic and Pre-cirrhotic NASH Patients”	HepaStem	Completed	NASH	Phase 1/2	23	Interventional	Belgium, Spain
NCT00956891	“Therapeutic Effects of Liver Failure Patients Caused by Chronic Hepatitis B After Autologous MSCs Transplantation”	Autologous MSCs	Completed	Liver failure	N/A	158	Observational	China
NCT02727673	“Relationship Between Circulating Tumor Stem Cells and the Clinical Pathology”	Tumor stem cells	Completed	HCC	N/A	1000	Observational	China
NCT00358501	“Defibrotide for the Treatment of Severe Hepatic Veno-Occlusive Disease in Hematopoetic Stem Cell Transplant Patients”	Hematopoetic stem cells	Completed	Severe hepatic veno-occlusive disease	Phase 3	134	Interventional	United States, Canada
NCT00007813	“Peripheral Stem Cell Transplantation Plus Chemotherapy in Treating Patients With Malignant Solid Tumors”	Peripheral stem cells	Completed	Liver cancer	Phase 1	21	Interventional	United States
NCT04423237	“Risk Factors and Measures to Prevent Liver and Pancreas Complications in Pediatric Patients After HSCT”	Hematopoetic stem cells	Completed	Liver complication	N/A	39	Observational	Italy
NCT03511794	“Effectiveness of the Hepatitis B Vaccine Post-Hematopoietic Stem Cell Transplant”	Hematopoetic stem cells	Completed	Hepatitis B	N/A	52	Observational	United States
NCT01481649	“Risk of Hepatitis B Reactivation After Bone Marrow Transplantation With Prior Hepatitis B Virus (HBV) Exposure”	Stem cells	Completed	Exposure to hepatitis B virus	N/A	69	Observational	China
NCT00002515	“Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer”	Stem cells	Completed	HCC	Phase 2	N/A	Interventional	United States
NCT06892236	“Preparation of IPSC for Cell Gene Editing for the Treatment of AATD”	hiPSCs	Recruiting	Alpha1-antitrypsin deficiency	NA	3	Interventional	Italy
NCT06242405	“Effect of Different Frequencies of Umbilical Cord-MSCs Through Peripheral Vein in Patients with ESLD”	UC-MSCs	Recruiting	End-stage liver disease	NA	92	Interventional	China
NCT06564740	“Stem Cell Applications in Biliary Atresia Patients”	Stem cells	Recruiting	Liver fibrosis (biliary atresia)	NA	64	Interventional	Turkey
NCT06740149	“Efficacy and Safety of BMSCs (CG-BM1) for ACLF Patients”	BM-MSCs	Recruiting	ACLF	Phase 1/2	90	Interventional	China
NCT06904755	“Safety and Effectiveness of MSCs in Blood Purification for the Treatment of Liver Failure”	MSCs	Recruiting	Liver failure	Phase 1	10	Interventional	China
NCT05106972	“Umbilical Cord MSC Transplantation for Decompensated Hepatitis B Cirrhosis”	UC-MSCs	Recruiting	Liver cirrhosis	NA	30	Interventional	China
NCT05985863	“Human Umbilical Cord MSC Transplantation for The Treatment of Acute-on-Chronic Liver Failure”	UC-MSCs	Recruiting	ACLF	Phase 1/2	150	Interventional	China
NCT04689152	“Clinical Trial to Evaluate the Efficacy and Safety of Cellgram-LC Administration in Patients With Alcoholic Cirrhosis”	Cellgram-LC	Recruiting	Alcoholic cirrhosis	Phase 3	200	Interventional	South Korea
NCT03826433	“hUC-MSCs (19#iSCLife®-LC) in the Treatment of Decompensated Hepatitis b Cirrhosis hepatitis b Cirrhosis”	UC-MSCs	Recruiting	Hepatitis B	Phase 1	20	Interventional	China
NCT00382278	“Safety Study of Autologous Stem Cell in Liver Cirrhosis”	Autologous stem cells	Terminated	Liver cirrhosis	Phase 1/2	15	Interventional	Brazil
NCT03860155	“Allogeneic ABCB5-positive Stem Cells for Treatment of Acute-on-Chronic Liver Failure”	Allogeneic stem cells	Terminated	ACLF	Phase 1/2	5	Interventional	Germany
NCT00923052	“The Natural History of Solid Organ Cancer Stem Cells (SOCSC)”	Cancer stem cells	Terminated	Hepatic cancer	N/A	190	Observational	United States

hiPSCs: Human induced pluripotent stem cells; MSCs: Mesenchymal stem/stromal cells; BM-EPCs: Bone marrow-derived endothelial progenitor cells; UC-MSCs: Umbilical cord-derived mesenchymal stem/stromal cells; BM-MSCs: Bone marrow-derived mesenchymal stem/stromal cells; HCC: Hepatocellular carcinoma; NASH: Non-alcoholic steatohepatitis; ACLF: Acute-on-chronic liver failure; N/A: Not Applicable; NA: Not Available.