Application of stem cells in the precise diagnosis and treatment of liver diseases

Table 3 Clinical trials of liver organoids for liver diseases

NCT No.	Study title	Study status	Condition	Enrollment	Study type	Location
NCT06929845	“Organoid Models of Hepatocellular Carcinoma”	Recruiting	HCC	150	Interventional	Italy
NCT02436564	“In Vitro Models of Liver and Pancreatic Cancer”	Unknown	Cholangiocarcinoma	75	Observational	United Kingdom
NCT05913141	“PDO/PDO-TIL/PDOTS for Drug Screen”	Recruiting	HCC	30	Observational	China
NCT06077591	“Prospective Clinical Validation of Next Generation Sequencing and Patient-Derived Tumor Organoids (PDO) Guided Therapy in Patients with Advanced/ Inoperable Solid Tumors”	Recruiting	HCC	40	Interventional	China
NCT06355700	“Hepatocellular Carcinoma Liver Organoids”	Recruiting	HCC	10	Interventional	Italy
NCT06699524	“Construction of a Recurrence Risk Prediction Model for Liver Resection Based on Drug Sensitivity of Patient-derived Hepatocellular Carcinoma Organoid”	Active not recruiting	HCC	122	Observational	China
NCT06856252	“Human Liver Organoids as a Model to Study the Development of NASH”	Recruiting	NASH	60	Interventional	Italy
NCT06787625	“Development of Organoids From Primary Colorectal Tumors and Synchronous Liver Metastases”	Recruiting	Colorectal cancer	10	Observational	Italy
NCT05932836	“An Organoid-on-chips Technique Based on Biopsy Samples and Its Efficacy in Predicting the Response to HAI in HCC”	Active not recruiting	HCC	165	Observational	China

HCC: Hepatocellular carcinoma; NASH: Non-alcoholic steatohepatitis.